Zorevunersen

Zorevunersen用途

Zorevunersen(STK-001)是一种反义寡核苷酸,旨在提高SCN1A mRNA的产量,从而提高钠通道Nav1.1蛋白的表达。Zorevunersen用于Dravet综合征的研究。

Zorevunersen名称

[ CAS 号 ]:
2415330-04-8

[ 英文名 ]:
Zorevunersen

Zorevunersen生物活性

[ 描述 ]:

Zorevunersen(STK-001)是一种反义寡核苷酸,旨在提高SCN1A mRNA的产量,从而提高钠通道Nav1.1蛋白的表达。Zorevunersen用于Dravet综合征的研究。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钠通道

研究领域 >> 其他

[ 靶点 ]

Nav1.1

[参考文献]

[1]. Wengert ER, Wagley PK, Strohm SM, et al. Targeted Augmentation of Nuclear Gene Output (TANGO) of Scn1a rescues parvalbumin interneuron excitability and reduces seizures in a mouse model of Dravet Syndrome. Brain Res. 2022;1775:147743.

[2]. Bialer M, Johannessen SI, Koepp MJ, et al. Progress report on new antiepileptic drugs: A summary of the Sixteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVI): II. Drugs in more advanced clinical development. Epilepsia. 2022;63(11):2883-2910.

Zorevunersen物理化学性质

[ 分子式 ]:
C₂₀₄H₂₆₃N₆₃O₁₁₄P₂₀S₂₀

[ 分子量 ]:
6682.39

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相关化合物

[Zorevunersen]化源网提供ZorevunersenCAS号2415330-04-8，ZorevunersenMSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询Zorevunersen上化源网，专业又轻松。>>电脑版：Zorevunersen

标题：【Zorevunersen】Zorevunersen CAS号:2415330-04-8【结构式性质活性】-化源网地址：https://www.chemsrc.com/amp/cas/2415330-04-8_1729251.html