Hyperforin dicyclohexylammonium salt

Hyperforin dicyclohexylammonium salt用途

Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) 是一种瞬时受体典型 6 (TRPC6) 通道激活剂。Hyperforin dicyclohexylammonium salt 通过激活 Ca2+ 传导非选择性典型 TRPC6 通道来调节 Ca2+ 水平。Hyperforin dicyclohexylammonium salt 具有抗抑郁作用。

Hyperforin dicyclohexylammonium salt名称

[ CAS 号 ]:
238074-03-8

[ 英文名 ]:
Hyperforin dicyclohexylammonium salt

[英文别名 ]:

hyperforin dicyclohexylammonium salt
Hyp-DCHA Hyperforin-DCHA
Hyp-DCHA
Hyperforin-DCHA

Hyperforin dicyclohexylammonium salt生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钙通道

信号通路 >> 跨膜转运 >> TRP频道

研究领域 >> 神经疾病

[体外研究]

高福林二环己基铵盐(Hyperforin-DCHA)具有多向作用机制。它阻断配体门控(GABA、NMDA和AMPA受体)和电压门控通道(Ca2+、K+和Na+)[2]的电导。

[参考文献]

[1]. Heiser JH, et al. TRPC6 channel-mediated neurite outgrowth in PC12 cells and hippocampal neurons involves activation of RAS/MEK/ERK, PI3K, and CAMKIV signaling. J Neurochem. 2013 Nov;127(3):303-13.

[2]. Pochwat B, et al. Hyperforin Potentiates Antidepressant-Like Activity of Lanicemine in Mice. Front Mol Neurosci. 2018 Dec 12;11:456.

Hyperforin dicyclohexylammonium salt物理化学性质

[ 分子式 ]:
C₄₇H₇₅NO₄

[ 分子量 ]:
718.10300

[ 精确质量 ]:
717.57000

[ PSA ]:
83.47000

[ LogP ]:
12.62200

[ 储存条件 ]:
-20°C，密闭，干燥

Hyperforin dicyclohexylammonium salt安全信息

[ 符号 ]:

GHS05, GHS07, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H314-H400

[ 警示性声明 ]:
P273-P280-P305 + P351 + P338-P310

[ 危险品运输编码 ]:
UN 1759 8 / PGIII

Hyperforin dicyclohexylammonium salt文献

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Clin. Cancer Res. 15 , 6852-61, (2009)

Signal transducer and activator of transcription-3 (STAT3) is downstream of growth factor and cytokine receptors, and regulates key oncogenic pathways in non-small cell lung cancer (NSCLC). Activation...

Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a.

Cancer Res. 70 , 9185-96, (2010)

Increasing evidence points to the functional importance of alternative splice variations in cancer pathophysiology. Two splice variants are derived from the CASP9 gene via the inclusion (Casp9a) or ex...

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