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N-(3-乙酰基-4-(2-羟基-3-(异丙基氨基)丙氧基)苯基)乙酰胺

用途

双丙酮醇是β肾上腺素受体阻断剂阿塞布洛尔(HY-17497)的活性代谢产物[1]。

名称

[ CAS 号 ]:
22568-64-5

[ 中文名 ]:
醋丁洛尔杂质B

[ 英文名 ]:
Diacetolol

[中文别名 ]:

醋丁洛尔EP杂质B

[英文别名 ]:

Acebutolol impurity B
Diacetolol
EINECS 245-088-3

生物活性

[ 描述 ]:

双丙酮醇是β肾上腺素受体阻断剂阿塞布洛尔(HY-17497)的活性代谢产物[1]。

[ 相关类别 ]:

研究领域 >> 心血管疾病

研究领域 >> 内分泌

[参考文献]

[1]. B Basil, R Jordan, et al. Pharmacological properties of diacetolol (M & B 16,942), a major metabolite of acebutolol. Eur J Pharmacol. 1982 May 7;80(1):47-56.

物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
548.8±50.0 °C at 760 mmHg

[ 分子式 ]:
C₁₆H₂₄N₂O₄

[ 分子量 ]:
308.37

[ 闪点 ]:
285.7±30.1 °C

[ 精确质量 ]:
308.173615

[ PSA ]:
91.15000

[ LogP ]:
0.89

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.551

[ 储存条件 ]:
2-8°C

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AB4205000

CHEMICAL NAME :: Acetamide, N-(3-acetyl-4-(2-hydroxy-3-((1-methylethyl)amino)prop oxy)phenyl)-, (+-)-

CAS REGISTRY NUMBER :: 22568-64-5

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H24-N2-O4

MOLECULAR WEIGHT :: 308.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 77600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NPMDAD Nouvelle Presse Medicale. (Paris, France) V.1-11, 1972-82. Volume(issue)/page/year: 7,3258,1978

安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2924299090

海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

文献

Using supported liquid extraction together with cellobiohydrolase chiral stationary phases-based liquid chromatography with tandem mass spectrometry for enantioselective determination of acebutolol and its active metabolite diacetolol in spiked human plasma.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(3) , 173-80, (2009)

A high through-put, sensitive, and enantioselective LC-MS/MS-based bioanalytical method was developed and validated for the simultaneous determination of individual acebutolol (AC) and its active meta...

Acebutolol: a review of its pharmacology, pharmacokinetics, clinical uses, and adverse effects.

Pharmacotherapy 6(2) , 45-63, (1986)

Acebutolol is a new hydrophilic, cardioselective beta-adrenergic-blocking agent that possesses partial agonist and membrane-stabilizing activities. In the treatment of mild to moderate essential hyper...

Preliminary study of the disposition in man of acebutolol and its metabolite, diacetolol, using a new stereoselective hplc method.

J. Pharm. Pharmacol. 36(4) , 276-7, (1984)

A new stereospecific hplc method that is capable of simultaneously quantitating the S-(-)- and R-(+)-enantiomers of acebutolol and its major metabolite, diacetolol, in plasma and urine, is described. ...

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