N-(3-乙酰基-4-(2-羟基-3-(异丙基氨基)丙氧基)苯基)乙酰胺结构式
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常用名 | N-(3-乙酰基-4-(2-羟基-3-(异丙基氨基)丙氧基)苯基)乙酰胺 | 英文名 | Diacetolol |
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| CAS号 | 22568-64-5 | 分子量 | 308.37 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 548.8±50.0 °C at 760 mmHg | |
| 分子式 | C16H24N2O4 | 熔点 | N/A | |
| MSDS | N/A | 闪点 | 285.7±30.1 °C |
用途双丙酮醇是β肾上腺素受体阻断剂阿塞布洛尔(HY-17497)的活性代谢产物[1]。 |
| 中文名 | 醋丁洛尔杂质B |
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| 英文名 | rac Diacetolol |
| 中文别名 | 醋丁洛尔EP杂质B |
| 英文别名 | 更多 |
| 描述 | 双丙酮醇是β肾上腺素受体阻断剂阿塞布洛尔(HY-17497)的活性代谢产物[1]。 |
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| 相关类别 | |
| 参考文献 |
| 密度 | 1.2±0.1 g/cm3 |
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| 沸点 | 548.8±50.0 °C at 760 mmHg |
| 分子式 | C16H24N2O4 |
| 分子量 | 308.37 |
| 闪点 | 285.7±30.1 °C |
| 精确质量 | 308.173615 |
| PSA | 91.15000 |
| LogP | 0.89 |
| 蒸汽压 | 0.0±1.6 mmHg at 25°C |
| 折射率 | 1.551 |
| 储存条件 | 2-8°C |
| 危险品运输编码 | NONH for all modes of transport |
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| 海关编码 | 2924299090 |
| 海关编码 | 2924299090 |
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| 中文概述 | 2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0% |
| 申报要素 | 品名, 成分含量, 用途, 包装 |
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Using supported liquid extraction together with cellobiohydrolase chiral stationary phases-based liquid chromatography with tandem mass spectrometry for enantioselective determination of acebutolol and its active metabolite diacetolol in spiked human plasma.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(3) , 173-80, (2009) A high through-put, sensitive, and enantioselective LC-MS/MS-based bioanalytical method was developed and validated for the simultaneous determination of individual acebutolol (AC) and its active meta... |
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Acebutolol: a review of its pharmacology, pharmacokinetics, clinical uses, and adverse effects.
Pharmacotherapy 6(2) , 45-63, (1986) Acebutolol is a new hydrophilic, cardioselective beta-adrenergic-blocking agent that possesses partial agonist and membrane-stabilizing activities. In the treatment of mild to moderate essential hyper... |
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Preliminary study of the disposition in man of acebutolol and its metabolite, diacetolol, using a new stereoselective hplc method.
J. Pharm. Pharmacol. 36(4) , 276-7, (1984) A new stereospecific hplc method that is capable of simultaneously quantitating the S-(-)- and R-(+)-enantiomers of acebutolol and its major metabolite, diacetolol, in plasma and urine, is described. ... |
| N-{3-Acetyl-4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl}acetamide |
| N-{3-Acetyl-4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl}acetami de |
| Acebutolol impurity B |
| N-{3-acetyl-4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}acetamide |
| N-{3-Acetyl-4-{(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy}phenyl}acetamide |
| Acetamide, N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]- |
| Diacetolol |
| EINECS 245-088-3 |
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