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2,4-二氯苯乙酮

2,4-二氯苯乙酮用途

用作医药中间体，用于合成酮康唑药物

2,4-二氯苯乙酮名称

[ CAS 号 ]:
2234-16-4

[ 中文名 ]:
2,4-二氯苯乙酮

[ 英文名 ]:
2',4'-Dichloroacetophenone

[中文别名 ]:

[英文别名 ]:

2,4-dichoroacetophenone
Acetophenone,2',4'-dichloro
2‘,4‘-Dichloroacetophenone
2,4-Dichloroacetophenone
2',4'-dichloro phenyl ethanone
(2,4-Cl2-Ph)COMe
EINECS 218-780-8
1-(2,4-dichlorophenyl)ethanone
2’,4’-Dichloroacetophenone
p-Chloro-2-chloroacetophenone

2,4-二氯苯乙酮物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
246.7±20.0 °C at 760 mmHg

[ 熔点 ]:
33-34 °C(lit.)

[ 分子式 ]:
C₈H₆Cl₂O

[ 分子量 ]:
189.039

[ 闪点 ]:
100.9±22.3 °C

[ 精确质量 ]:
187.979568

[ PSA ]:
17.07000

[ LogP ]:
2.79

[ 外观性状 ]:
白色至灰白色晶体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.549

[ 储存条件 ]:
室温，密封

[ 水溶解性 ]:
ca. 200 mg/L

2,4-二氯苯乙酮MSDS

2,4-二氯苯乙酮安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H318

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R52/53

[ 安全声明 (欧洲) ]:
S26-S39-S61

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ 海关编码 ]:
2914700090

2,4-二氯苯乙酮合成路线

2,4-二氯苯乙酮上下游产品

2,4-二氯苯乙酮上游产品

2,4-二氯苯乙酮下游产品

2,4-二氯苯乙酮制备

其制备方法是在反应瓶中加入间二氯苯，升温至50℃，搅拌下加入适量的无水三氯化铝，保持温度50℃，滴加乙酰氯，滴完后逐渐升温至100℃，并在该温度下搅拌8h，反应结束后，在反应液中加入二氯甲烷并倒入水中，放置冷却，分出油层，水层用二氯甲烷萃取，并入有机层，用水洗涤有机层，干燥，蒸去溶剂减压蒸馏，收集160～180℃/0.015 MPa馏分，得到白色结晶为2，4-二氯苯乙酮。

2,4-二氯苯乙酮海关

[ 海关编码 ]: 2914700090

[ 中文概述 ]:
2914700090 其他酮及醌的卤化、磺化衍生物（包括硝化和亚硝化衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

2,4-二氯苯乙酮文献

Glutathione-dependent reductive dehalogenation of 2,2',4'-trichloroacetophenone to 2',4'-dichloroacetophenone.

Biochem. Pharmacol. 31(23) , 3885-90, (1982)

alpha-Haloketones are highly reactive compounds, which are known to undergo enzymatic reduction to methyl ketones. The objective of this research was to characterize the enzymes involved in this react...

[Synthesis of a new cyclodextrin derivative and its application as CGC chiral stationary phase in determination of enantiomeric excess].

Se Pu 20(1) , 34-6, (2002)

A new cyclodextrin (CD) derivative, 2,6-di-O-benzyl-3-O-valeryl-beta-CD, was synthesized and characterized by 1H NMR and IR. Using the beta-CD derivative as chiral stationary phase of capillary gas ch...

Microwave assisted rapid and efficient synthesis of nitrogen and sulphur containing heterocyclic compounds and their pharmacological evaluation.

Indian J. Chem. B 45(7) , 1762, (2006)

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