N-丁基-N-乙基-2,5,6-三甲基-7-(2,4,6-三甲基苯基)-7H-吡咯并[2,3-d]嘧啶基-4-胺盐酸盐

用途

安他拉明(盐酸)是一种非肽促肾上腺皮质激素释放激素受体1(CRHR1)拮抗剂,Ki为1nM。盐酸安塔拉明抑制动物模型中CRH诱导的ACTH分泌,阻断CRH和新奇感诱导的焦虑样行为。盐酸安塔拉明在关节炎模型中产生抗炎作用,并抑制与肠易激综合征相关的应激性胃溃疡[1][2][3]。

名称

[ CAS 号 ]:
220953-69-5

[ 中文名 ]:
N-丁基-N-乙基-2,5,6-三甲基-7-(2,4,6-三甲基苯基)-7H-吡咯并[2,3-d]嘧啶基-4-胺盐酸盐

[ 英文名 ]:
Antalarmin hydrochloride

[英文别名 ]:

生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 内分泌

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Webster EL, et al. In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation. Endocrinology. 1996 Dec;137(12):5747-50. doi: 10.1210/endo.137.12.8940412.

[2]. Zorrilla EP, et al. Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat. Brain Res. 2002 Oct 18;952(2):188-99.

[3]. Deak T, et al. The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress. Endocrinology. 1999 Jan;140(1):79-86.

物理化学性质

[ 分子式 ]:
C₂₄H₃₅ClN₄

[ 分子量 ]:
415.014

[ 精确质量 ]:
414.255035

[ PSA ]:
33.95000

[ LogP ]:
6.69930

[ 储存条件 ]:
-20°C，密闭，干燥

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

文献

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