<生产厂家价格>

NG,NG-dimethyl-L-Arginine hydrochloride

NG,NG-dimethyl-L-Arginine hydrochloride用途

不对称二甲基精氨酸二盐酸盐是一种内源性NO合成酶抑制剂,可减少NO的产生,从而导致内皮功能障碍和心血管疾病[1]。

NG,NG-dimethyl-L-Arginine hydrochloride名称

[ CAS 号 ]:
220805-22-1

[ 中文名 ]:
不对称二甲基精氨酸二盐酸盐溶液,100PPM

[ 英文名 ]:
NG,NG-Dimethylarginine Dihydrochloride

[英文别名 ]:

asym-Dimethylarginine ADMA
NG,NG-Dimethylarginine dihydrochloride
MFCD00270857
NG,NG-DimethylarginineDihydrochloride

NG,NG-dimethyl-L-Arginine hydrochloride生物活性

[ 描述 ]:

不对称二甲基精氨酸二盐酸盐是一种内源性NO合成酶抑制剂,可减少NO的产生,从而导致内皮功能障碍和心血管疾病[1]。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 免疫及炎症 >> 一氧化氮合酶

[参考文献]

[1]. Latika Sibal, et al. The Role of Asymmetric Dimethylarginine (ADMA) in Endothelial Dysfunction and Cardiovascular Disease. Curr Cardiol Rev. 2010 May;6(2):82-90.

NG,NG-dimethyl-L-Arginine hydrochloride物理化学性质

[ 沸点 ]:
427.5ºC at 760 mmHg

[ 熔点 ]:
202-204OºC

[ 分子式 ]:
C₈H₂₀Cl₂N₄O₂

[ 分子量 ]:
275.18

[ 闪点 ]:
212.4ºC

[ 精确质量 ]:
274.096344

[ PSA ]:
102.44000

[ LogP ]:
2.05940

[ 蒸汽压 ]:
1.66E-08mmHg at 25°C

[ 储存条件 ]:
-20°C，密闭，干燥

NG,NG-dimethyl-L-Arginine hydrochlorideMSDS

详细MSDS(安全技术说明书)

NG,NG-dimethyl-L-Arginine hydrochloride安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

NG,NG-dimethyl-L-Arginine hydrochloride文献

Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2.

J. Biol. Chem. 290 , 16723-43, (2015)

Human protein arginine methyltransferase (PRMT) 9 symmetrically dimethylates arginine residues on splicing factor SF3B2 (SAP145) and has been functionally linked to the regulation of alternative splic...

PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145.

Nat. Commun. 6 , 6428, (2015)

The human genome encodes a family of nine protein arginine methyltransferases (PRMT1-9), whose members can catalyse three distinct types of methylation on arginine residues. Here we identify two splic...

Effects of nitric oxide synthase deficiency on a disintegrin and metalloproteinase domain-containing protein 12 expression in mouse brain samples.

Mol. Med. Report. 12 , 2253-62, (2015)

A disintegrin and metalloproteinase domain-containing protein 12 (ADAM12) belongs to the ADAM family of transmembrane proteins. Via proteolysis, cell adhesion, cell-cell fusion, cell-matrix interactio...

更多文献