<生产厂家价格>

盐酸石蒜碱

盐酸石蒜碱用途

Lycorine (hydrochloride) 是一种 VE-cadherin 抑制剂,在 Hey1B细胞中的 IC50为1.2μM。

盐酸石蒜碱名称

[ CAS 号 ]:
2188-68-3

[ 中文名 ]:
盐酸石蒜碱

[ 英文名 ]:
Lycorine chloride

[中文别名 ]:

[英文别名 ]:

Lycorine hydrochloride
Lycorinehydrochloride
Licorin hydrochloride
galanthidine,hydrochloride
Lycorinechloride
Lycorine (hydrochloride)

盐酸石蒜碱生物活性

[ 描述 ]:

Lycorine (hydrochloride) 是一种 VE-cadherin 抑制剂,在 Hey1B细胞中的 IC50为1.2μM。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

天然产物 >> 生物碱

研究领域 >> 癌症

[参考文献]

[1]. Liu, R. et al. Lycorine hydrochloride inhibits metastatic melanoma cell-dominant vasculogenic mimicry. Pigment cell & melanoma research 25, 630-638, doi:10.1111/j.1755-148X.2012.01036.x (2012).

[2]. Cao, Z. et al.Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity. Toxicology letters 218, 174-185, doi:10.1016/j.toxlet.2013.01.018 (2013).

[相关活性小分子]

盐酸石蒜碱物理化学性质

[ 沸点 ]:
477.4ºC at 760 mmHg

[ 熔点 ]:
210-212ºC

[ 分子式 ]:
C₁₆H₁₈ClNO₄

[ 分子量 ]:
323.77

[ 闪点 ]:
242.5ºC

[ PSA ]:
62.16000

[ LogP ]:
0.68650

[ 外观性状 ]:
细晶体粉末

[ 蒸汽压 ]:
6.37E-10mmHg at 25°C

[ 储存条件 ]:
2-8°C

盐酸石蒜碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OL2910000

CHEMICAL NAME :: Lycoran-1-alpha,2-beta-diol, 3,3-alpha-didehydro-, hydrochloride

CAS REGISTRY NUMBER :: 2188-68-3

LAST UPDATED :: 198803

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C16-H17-N-O4.Cl-H

MOLECULAR WEIGHT :: 323.80

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 230 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 54,21,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 117 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 54,21,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 123 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - nausea or vomiting

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 54,21,1958

盐酸石蒜碱安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
R25

[ 安全声明 (欧洲) ]:
45

[ 危险品运输编码 ]:
UN 2811

[ 危险类别 ]:
6.1

盐酸石蒜碱文献

Comparison of anti-acetylcholinesterase activity of bulb and leaf extracts of Sternbergia candida Mathew & T. Baytop.

Acta Biol. Hung. 65(4) , 396-404, (2014)

Studies on Alzheimer's disease have been highlighted due to increasing prevalence of this disease. Oldest hypothesis about the pathophysiology strengthens the research of cholinesterase inhibitors for...

[Study on the chemical constituents from the bulbs of Zephyranthes candida].

Zhong Yao Cai 33(11) , 1730-2, (2010)

To study the chemical constituents from the bulbs of Zephyranthes candida.The chemical constituents were separated and purified by means of several chromatographies and their structures were elucidate...

Copper-induced synthesis of ascorbate, glutathione and phytochelatins in the marine alga Ulva compressa (Chlorophyta).

Plant Physiol. Biochem. 51 , 102-8, (2012)

In order to analyze the synthesis of antioxidant and heavy metal-chelating compounds in response to copper stress, the marine alga Ulva compressa (Chlorophyta) was exposed to 10 μM copper for 7 days a...

更多文献