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3-氰基伞形酮

3-氰基伞形酮用途

3-氰基茴香酮是一种香豆素衍生物,用作分子探针和荧光染料。3-氰基茴香酮也是一种巨噬细胞迁移抑制因子(MIF)互变异构酶抑制剂,Ki为2.9μM[1]。

3-氰基伞形酮名称

[ CAS 号 ]:
19088-73-4

[ 中文名 ]:
3-氰基-7-羟基香豆素

[ 英文名 ]:
7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBONITRILE

[中文别名 ]:

[英文别名 ]:

3-Cyano-7-hydroxycoumarin
7-hydroxy-2-oxochromene-3-carbonitrile
7-Hydroxy-2-oxo-2H-chromene-3-carbonitrile

3-氰基伞形酮生物活性

[ 描述 ]:

3-氰基茴香酮是一种香豆素衍生物,用作分子探针和荧光染料。3-氰基茴香酮也是一种巨噬细胞迁移抑制因子(MIF)互变异构酶抑制剂,Ki为2.9μM[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[ 靶点 ]

Ki: 2.9 μM (MIF)[1]

[参考文献]

[1]. Orita M, et al. Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography. J Med Chem. 2001 Feb 15;44(4):540-7.

3-氰基伞形酮物理化学性质

[ 密度 ]:
1.5 g/cm3

[ 沸点 ]:
436.6ºC at 760 mmHg

[ 熔点 ]:
≥250ºC(lit.)

[ 分子式 ]:
C₁₀H₅NO₃

[ 分子量 ]:
187.15200

[ 闪点 ]:
217.8ºC

[ 精确质量 ]:
187.02700

[ PSA ]:
74.23000

[ LogP ]:
1.37028

[ 外观性状 ]:
固体;Light orange to Yellow to Green powder to crystal

[ 蒸汽压 ]:
3.13E-08mmHg at 25°C

[ 折射率 ]:
1.667

[ 储存条件 ]:
室温

[ 水溶解性 ]:
DMF: soluble

3-氰基伞形酮MSDS

3-氰基伞形酮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H312 + H332-H315-H319-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2932209090

3-氰基伞形酮合成路线

3-氰基伞形酮上下游产品

3-氰基伞形酮上游产品

3-氰基伞形酮下游产品

3-氰基伞形酮海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

3-氰基伞形酮文献

Potent inhibition of CYP1A2 by Frutinone A, an active ingredient of the broad spectrum antimicrobial herbal extract from P. fruticosa.

Xenobiotica 42 , 989-1000, (2012)

1. Frutinone is an active ingredient extracted from the lipophilic fraction of the Polygala Fruticosa demonstrating various antibacterial and fungal properties. The aim of this study was to characteri...

A continuous fluorometric assay for cytochrome P-450-dependent mixed function oxidases using 3-cyano-7-ethoxycoumarin.

Anal. Biochem. 172 , 304, (1988)

A direct fluorometric procedure for the continuous determination of cytochrome P-450-dependent mixed function oxidases, using 3-cyano-7-ethoxycoumarin substrate, is described. The reaction product, 3-...

Assessment of cytochrome P450 fluorometric substrates with rainbow trout and killifish exposed to dexamethasone, pregnenolone-16alpha-carbonitrile, rifampicin, and beta-naphthoflavone.

Aquat. Toxicol. 97 , 324-333, (2010)

Cytochrome P450s (CYPs) are important xenobiotic metabolizing proteins. While their functions are well understood in mammals, CYP function in non-mammalian vertebrate systems is much less defined, wit...

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