1-(2,4-二氯苯基)-5-(4-碘苯基)-4-甲基-N-(哌啶-1-基)-1H-吡唑-3-甲酰胺
用途
名称
[ CAS 号 ]:
183232-66-8
[ 中文名 ]:
1-(2,4-二氯苯基)-5-(4-碘苯基)-4-甲基-N-1-哌啶基-1H-吡唑-3-羧胺
[ 英文名 ]:
AM251
[中文别名 ]:
[英文别名 ]:
- AM-251
- Tocris-1117
- AM251
生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
IC50: 8 nM (CB1 receptor)[1]
[体外研究]
[体内研究]
[激酶实验]
[动物实验]
[参考文献]
[相关活性小分子]
物理化学性质
[ 密度 ]:
1.7±0.1 g/cm3
[ 熔点 ]:
195-196℃
[ 分子式 ]:
C22H21Cl2IN4O
[ 分子量 ]:
555.239
[ 精确质量 ]:
554.013672
[ PSA ]:
50.16000
[ LogP ]:
6.45
[ 外观性状 ]:
一种结晶固体
[ 折射率 ]:
1.703
[ 储存条件 ]:
Store at RT
[ 水溶解性 ]:
DMSO: >10 mg/mL, soluble
安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H315-H319-H335
[ 警示性声明 ]:
P261-P305 + P351 + P338
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves
[ 危害码 (欧洲) ]:
Xi: Irritant;
[ 风险声明 (欧洲) ]:
R36/37/38
[ 安全声明 (欧洲) ]:
26-36
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
3
文献
Proc. Natl. Acad. Sci. U. S. A. 111(52) , E5706-15, (2014)
An shRNA-mediated screen of the 48 human nuclear receptor genes identified multiple candidates likely to influence the production of human cytomegalovirus in cultured human fibroblasts, including the ...
Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid.Carcinogenesis 35(12) , 2787-97, (2014)
Cannabigerol (CBG) is a safe non-psychotropic Cannabis-derived cannabinoid (CB), which interacts with specific targets involved in carcinogenesis. Specifically, CBG potently blocks transient receptor ...
2-Arachidonoylglycerol impairs human cytotrophoblast cells syncytialization: influence of endocannabinoid signalling in placental development.Mol. Cell. Endocrinol. 399 , 386-94, (2014)
A balanced cytotrophoblast cell turnover is crucial for placental development and anomalies in this process associated with gestational diseases. The endocannabinoid system (ECS) has emerged as a new ...
推荐生产厂家/供应商:
公司名:上海源溪生物科技有限公司
区域:上海市浦东新区
价格:
¥需询单/1g
联系人:赖经理
产品详情:AM251
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥1750.9/25mg
¥4943.9/100mg
¥453.9/5mg
¥需询单/1g
联系人:阿拉丁李高志
产品详情:AM251
公司名:武汉敬康恩生物医药科技有限公司
区域:武汉市东西湖区
价格:
¥需询单/1g
联系人:周经理
产品详情:AM 251
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CAS号[183232-66-8]化源网提供[1-(2,4-二氯苯基)-5-(4-碘苯基)-4-甲基-N-(哌啶-1-基)-1H-吡唑-3-甲酰胺]MSDS、说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。>>电脑版:1-(2,4-二氯苯基)-5-(4-碘苯基)-4-甲基-N-(哌啶-1-基)-1H-吡唑-3-甲酰胺
标题:183232-66-8_CAS号:183232-66-8_1-(2,4-二氯苯基)-5-(4-碘苯基)-4-甲基-N-(哌啶-1-基)-1H-吡唑-3-甲酰胺 - 化源网 地址:https://www.chemsrc.com/amp/cas/183232-66-8_587378.html