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S-烯丙基-L-半胱氨酸

S-烯丙基-L-半胱氨酸用途

(±)-Alliin 是大蒜的主要活性成分。(±)-Alliin 被认为是 SARS-CoV-2 (Mpro) 的虚拟抑制剂。

S-烯丙基-L-半胱氨酸名称

[ CAS 号 ]:
17795-26-5

[ 中文名 ]:
(±)-L-蒜氨酸

[ 英文名 ]:
(±)-Alliin

[英文别名 ]:

3-[(S)-Allylsulfinyl]-L-alanine
alliin
3-(allylsulfinyl)-l-alanin
(±)-Alliin
L-Alanine, 3-[(S)-(1S)-2-propen-1-ylsulfinyl]-
ACSO,S-Allyl-L-cysteine sulfoxide,SAC
alliin zwitterion
ACSO S-Allyl-L-cysteine sulfoxide SAC

S-烯丙基-L-半胱氨酸生物活性

[ 描述 ]:

(±)-Alliin 是大蒜的主要活性成分。(±)-Alliin 被认为是 SARS-CoV-2 (Mpro) 的虚拟抑制剂。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> SARS冠状病毒

[体外研究]

分子对接技术用于评价不同药物与SARS-CoV-2主蛋白酶(Mpro)结合的稳定性。(±)-蒜氨酸与SARS冠状病毒Mpro在Leu-167、Met-49和Glu-166上有三个氢键相互作用；对于SARS-CoV-2 Mpro,(±)-蒜氨酸的对接位点为Cys-145、Met-49和Glu-166,并带有三个氢键[1]。

[参考文献]

[1]. Bijun Cheng, et al. Discovery of Alliin as a Putative Inhibitor of the Main Protease of SARS-CoV-2 by Molecular Docking. Biotechniques

S-烯丙基-L-半胱氨酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
416.1±45.0 °C at 760 mmHg

[ 分子式 ]:
C₆H₁₁NO₃S

[ 分子量 ]:
177.221

[ 闪点 ]:
205.5±28.7 °C

[ 精确质量 ]:
177.045959

[ PSA ]:
99.60000

[ LogP ]:
-0.48

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±2.1 mmHg at 25°C

[ 折射率 ]:
1.579

[ 储存条件 ]:
2-8°C

S-烯丙基-L-半胱氨酸MSDS

详细MSDS(安全技术说明书)

S-烯丙基-L-半胱氨酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 风险声明 (欧洲) ]:
36/37/38

[ 危险品运输编码 ]:
NONH for all modes of transport

S-烯丙基-L-半胱氨酸文献

Analytical method for simultaneous determination of bulk and intramolecular (13) C-isotope compositions of acetic acid.

Rapid Commun. Mass Spectrom. 29 , 2337-40, (2015)

Headspace solid-phase microextraction (HS-SPME) combined with gas chromatography/pyrolysis-gas chromatography/combustion-isotope ratio mass spectrometry (GC/Py-GC/C-IRMS) was developed for the simulta...

Metabolism, excretion, and pharmacokinetics of S-allyl-L-cysteine in rats and dogs.

Drug Metab. Dispos. 43(5) , 749-55, (2015)

The metabolism, excretion, and pharmacokinetics of S-allyl-l-cysteine (SAC), an active key component of garlic supplements, were examined in rats and dogs. A single dose of SAC was administered orally...

Combination of aqueous two-phase extraction and cation-exchange chromatography: New strategies for separation and purification of alliin from garlic powder

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 957 , 60-7, (2014)

In this study, a two-step process combining aqueous two-phase extraction (ATPE) with chromatography was developed for extraction and purification of alliin from garlic powder. The partition coefficien...

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