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6-.羟基氯唑沙宗

6-.羟基氯唑沙宗用途

6-Hydroxy Chlorzoxazone 是 Chlorzoxazone (HY-B1462) 的代谢物,Chlorzoxazone 是一种作用于中枢的肌肉松弛剂, 用于研究肌肉痉挛。

6-.羟基氯唑沙宗名称

[ CAS 号 ]:
1750-45-4

[ 中文名 ]:
6-羟基氯唑沙宗

[ 英文名 ]:
5-Chloro-6-hydroxy-1,3-benzoxazol-2(3H)-one

[中文别名 ]:

[英文别名 ]:

5-chloro-6-hydroxy-3H-1,3-benzoxazol-2-one
2(3H)-Benzoxazolone, 5-chloro-6-hydroxy-
5-Chloro-6-hydroxy-1,3-benzoxazol-2(3H)-one

6-.羟基氯唑沙宗生物活性

[ 描述 ]:

6-Hydroxy Chlorzoxazone 是 Chlorzoxazone (HY-B1462) 的代谢物,Chlorzoxazone 是一种作用于中枢的肌肉松弛剂, 用于研究肌肉痉挛。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

[参考文献]

[1]. Elbarbry F, et al. Studying the Inhibitory Effect of Quercetin and Thymoquinone on Human Cytochrome P450 Enzyme Activities. Pharmacogn Mag. 2018 Jan;13(Suppl 4):S895-S899.

6-.羟基氯唑沙宗物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 熔点 ]:
240-242ºC

[ 分子式 ]:
C₇H₄ClNO₃

[ 分子量 ]:
185.565

[ 精确质量 ]:
184.987976

[ PSA ]:
66.23000

[ LogP ]:
1.59

[ 外观性状 ]:
白色至粉红色

[ 折射率 ]:
1.651

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
methanol: soluble

6-.羟基氯唑沙宗MSDS

详细MSDS(安全技术说明书)

6-.羟基氯唑沙宗毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DM5260000

CHEMICAL NAME :: 2-Benzoxazolinone, 5-chloro-6-hydroxy-

CAS REGISTRY NUMBER :: 1750-45-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H4-Cl-N-O3

MOLECULAR WEIGHT :: 185.57

WISWESSER LINE NOTATION :: T56 BMVOJ GQ HG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDCHAG Medicinal Chemistry: A Series of Monographs. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1963- Volume(issue)/page/year: 4(1),340,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 550 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDCHAG Medicinal Chemistry: A Series of Monographs. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1963- Volume(issue)/page/year: 4(1),340,1964

6-.羟基氯唑沙宗安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
DM5260000

[ 海关编码 ]:
2934999090

6-.羟基氯唑沙宗上下游产品

6-.羟基氯唑沙宗上游产品

6-.羟基氯唑沙宗下游产品

6-.羟基氯唑沙宗海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

6-.羟基氯唑沙宗文献

Effect of commercially available green and black tea beverages on drug-metabolizing enzymes and oxidative stress in Wistar rats.

Food Chem. Toxicol. 70 , 120-7, (2014)

The effect of commercially available green tea (GT) and black tea (BT) drinks on drug metabolizing enzymes (DME) and oxidative stress in rats was investigated. Male Wistar rats were fed a laboratory c...

Novel Marmoset Cytochrome P450 2C19 in Livers Efficiently Metabolizes Human P450 2C9 and 2C19 Substrates, S-Warfarin, Tolbutamide, Flurbiprofen, and Omeprazole.

Drug Metab. Dispos. 43 , 1408-16, (2015)

The common marmoset (Callithrix jacchus), a small New World monkey, has the potential for use in human drug development due to its evolutionary closeness to humans. Four novel cDNAs, encoding cytochro...

Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration.

Toxicol. Sci. 143(1) , 107-15, (2014)

Acetaminophen (APAP) overdose is the most frequent cause of drug-induced acute liver failure. Schisandra sphenanthera is a traditional hepato-protective Chinese medicine and Schisandrol B (SolB) is on...

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