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1-乙基-1H-苯并[d]咪唑-2(3H)-酮

1-乙基-1H-苯并[d]咪唑-2(3H)-酮用途

1-EBIO是钙敏感钾通道的激活剂。1-EBIO用于研究K+通道在多种生理功能中的作用[1]。

1-乙基-1H-苯并[d]咪唑-2(3H)-酮名称

[ CAS 号 ]:
10045-45-1

[ 中文名 ]:
3-乙基-2-苯并咪唑酮

[ 英文名 ]:
1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one

[中文别名 ]:

[英文别名 ]:

2H-Benzimidazol-2-one, 1-ethyl-1,3-dihydro-
EINECS 233-148-1
1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one

1-乙基-1H-苯并[d]咪唑-2(3H)-酮生物活性

[ 描述 ]:

1-EBIO是钙敏感钾通道的激活剂。1-EBIO用于研究K+通道在多种生理功能中的作用[1]。

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> 跨膜转运 >> 钾通道

[参考文献]

[1]. Devor DC, et al. Modulation of Cl- secretion by benzimidazolones. I. Direct activation of a Ca(2+)-dependent K+ channel. Am J Physiol. 1996 Nov;271(5 Pt 1):L775-84.

1-乙基-1H-苯并[d]咪唑-2(3H)-酮物理化学性质

[ 密度 ]:
1.161±0.06 g/cm3

[ 熔点 ]:
122 ºC

[ 分子式 ]:
C₉H₁₀N₂O

[ 分子量 ]:
162.189

[ 精确质量 ]:
162.079315

[ PSA ]:
37.79000

[ LogP ]:
1.39

[ 外观性状 ]:
powder

[ 折射率 ]:
1.566

[ 储存条件 ]:
Store at RT

[ 水溶解性 ]:
Slightly soluble (1.6 g/L) (25 ºC)

1-乙基-1H-苯并[d]咪唑-2(3H)-酮MSDS

1-乙基-1H-苯并[d]咪唑-2(3H)-酮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22-36

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933990090

1-乙基-1H-苯并[d]咪唑-2(3H)-酮合成路线

1-乙基-1H-苯并[d]咪唑-2(3H)-酮上下游产品

1-乙基-1H-苯并[d]咪唑-2(3H)-酮上游产品

1-乙基-1H-苯并[d]咪唑-2(3H)-酮下游产品

1-乙基-1H-苯并[d]咪唑-2(3H)-酮海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1-乙基-1H-苯并[d]咪唑-2(3H)-酮文献

Differentiation between human ClC-2 and CFTR Cl- channels with pharmacological agents.

Am. J. Physiol. Cell Physiol. 307(5) , C479-92, (2014)

It has been difficult to separate/identify the roles of ClC-2 and CFTR in Cl(-) transport studies. Using pharmacological agents, we aimed to differentiate functionally between ClC-2 and CFTR Cl(-) cha...

Type 2 diabetes: increased expression and contribution of IKCa channels to vasodilation in small mesenteric arteries of ZDF rats.

Am. J. Physiol. Heart Circ. Physiol. 307(8) , H1093-102, (2014)

Impaired endothelial function, which is dysregulated in diabetes, also precedes hypertension. We hypothesized that in Type 2 diabetes, the impaired endothelium-dependent relaxation is due to a loss of...

Firing pattern modulation through SK channel current increase underlies neuronal survival in an organotypic slice model of Parkinson's disease.

Mol. Neurobiol. 51(1) , 424-36, (2015)

Dopaminergic (DA) neurons in substantia nigra pars compacta (SNc) are vulnerable to excitotoxicity in Parkinson's disease (PD). Neurotoxic stimuli may alter the firing patterns of DA neurons. However,...

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