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欧前胡素A(请核实!)

欧前胡素A(请核实!)用途

Imperatoxin A,一种源自非洲蝎子 Pandinus imperator 毒液的肽毒素,是 Ca2+-释放通道/兰尼碱受体 (RyRs) 的激活剂,可以促进 Ca2+ 从肌浆网流入细胞。

欧前胡素A(请核实!)名称

[ CAS 号 ]:
172451-37-5

[ 中文名 ]:
欧前胡素A(请核实!)

[ 英文名 ]:
Imperatoxin A

欧前胡素A(请核实!)生物活性

[ 描述 ]:

Imperatoxin A,一种源自非洲蝎子 Pandinus imperator 毒液的肽毒素,是 Ca2+-释放通道/兰尼碱受体 (RyRs) 的激活剂,可以促进 Ca2+ 从肌浆网流入细胞。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钙通道

[ 靶点 ]

RyRs[1]

[参考文献]

[1]. Georgina B Gurrola, et al. Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca2+-Release Channels/Ryanodine Receptors. Pharmaceuticals (Basel). 2010 Apr 1;3(4):1093-1107.

欧前胡素A(请核实!)物理化学性质

[ 分子式 ]:
C₁₄₈H₂₆₀N₅₈O₄₅S₆

[ 分子量 ]:
3764.4

[ 外观性状 ]:
lyophilized powder

[ 储存条件 ]:
−20°C

欧前胡素A(请核实!)安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
20/21/22

[ 安全声明 (欧洲) ]:
7-9-36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

欧前胡素A(请核实!)文献

Scorpion toxins targeted against the sarcoplasmic reticulum Ca(2+)-release channel of skeletal and cardiac muscle.

Proc. Natl. Acad. Sci. U. S. A. 89 , 12185-12189, (1992)

We report the purification of two peptides, called "imperatoxin inhibitor" and "imperatoxin activator," from the venom of the scorpion Pandinus imperator targeted against ryanodine receptor Ca(2+)-rel...

Peptide probe of ryanodine receptor function. Imperatoxin A, a peptide from the venom of the scorpion Pandinus imperator, selectively activates skeletal-type ryanodine receptor isoforms.

J. Biol. Chem. 270 , 28696-28704, (1995)

We have used [3H]ryanodine binding experiments and single channel recordings to provide convergent descriptions of the effect of imperatoxin A (IpTxa), a approximately 5-kDa peptide from the venom of ...

Primary structure and synthesis of Imperatoxin A (IpTx(a)), a peptide activator of Ca2+ release channels/ryanodine receptors.

FEBS Lett. 405 , 385-389, (1997)

We present the complete amino acid sequence of Imperatoxin A (IpTx(a)), a 33-amino-acid peptide from the venom of the scorpion P. imperator which activates Ca2+ release channels/ryanodine receptors (R...

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