Epsilon-(gamma-glutamyl)-lysine

Epsilon-(gamma-glutamyl)-lysine用途

Epsilon-(gamma-glutamyl)-lysine 是 N(6)-acyl-L-lysine 的衍生物。在一些疾病中 (如非糖尿病肾病,青光眼),组织转谷氨酰胺酶 (tTg) 使得 ECM 成分之间形成 Epsilon-(gamma-glutamyl)-lysine 键增加。

Epsilon-(gamma-glutamyl)-lysine名称

[ CAS 号 ]:
17105-15-6

[ 中文名 ]:
γ-Glu-ε-Lys(TFA)

[ 英文名 ]:
H-Glu(H-Lys-OH)-OH

[英文别名 ]:

H-Glu(H-Lys-OH)-OH
epsilon-(gamma-Glutamyl)-lysine

Epsilon-(gamma-glutamyl)-lysine生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[参考文献]

[1]. Siegfried G Priglinger, et al. Potential Role of Tissue Transglutaminase in Glaucoma Filtering Surgery. Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3835-45.

[2]. A M El Nahas, et al. Elevated Epsilon-(Gamma-Glutamyl)lysine in Human Diabetic Nephropathy Results From Increased Expression and Cellular Release of Tissue Transglutaminase.Nephron Clin Pract. 2004;97(3):c108-17.

Epsilon-(gamma-glutamyl)-lysine物理化学性质

[ 密度 ]:
1.29g/cm3

[ 沸点 ]:
610.3ºC at 760mmHg

[ 分子式 ]:
C₁₁H₂₁N₃O₅

[ 分子量 ]:
275.30200

[ 闪点 ]:
322.9ºC

[ 精确质量 ]:
275.14800

[ PSA ]:
155.74000

[ LogP ]:
0.66840

[ 蒸汽压 ]:
1.26E-16mmHg at 25°C

[ 折射率 ]:
1.538

Epsilon-(gamma-glutamyl)-lysineMSDS

Epsilon-(gamma-glutamyl)-lysine安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

Epsilon-(gamma-glutamyl)-lysine合成路线

Epsilon-(gamma-glutamyl)-lysine文献

In-vitro digestibility and amino acid composition of soy protein isolate cross-linked with microbial transglutaminase followed by heating with ribose.

Int. J. Food Sci. Nutr. 60 Suppl 7 , 99-108, (2009)

Cross-linked soy protein isolate (SPI) gels were produced via single-treatment of SPI with microbial transglutaminase (MTG) for 5 h or 24 h, or with ribose for 2 h, or via combined-treatments of SPI w...

Inhibition of transglutaminase activity reduces extracellular matrix accumulation induced by high glucose levels in proximal tubular epithelial cells.

J. Biol. Chem. 279(46) , 47754-62, (2004)

Diabetic nephropathy affects 30-40% of diabetics leading to end-stage kidney failure through progressive scarring and fibrosis. Previous evidence suggests that tissue transglutaminase (tTg) and its pr...

Identification and quantification of epsilon-(gamma-glutamyl)lysine in digests of enzymatically cross-linked leguminous proteins by high-performance liquid chromatography-electrospray ionization mass spectrometry (HPLC-ESI-MS).

J. Agric. Food Chem. 53(8) , 2830-7, (2005)

A rapid and convenient method for the precise quantification of epsilon-(gamma-glutamyl)lysine isopeptide in lyophilized proteolytic digests of cross-linked plant protein samples was developed. The is...

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Epsilon-(gamma-glutamyl)-lysine

Epsilon-(gamma-glutamyl)-lysine用途

Epsilon-(gamma-glutamyl)-lysine名称

Epsilon-(gamma-glutamyl)-lysine生物活性

Epsilon-(gamma-glutamyl)-lysine物理化学性质

Epsilon-(gamma-glutamyl)-lysineMSDS

详细MSDS(安全技术说明书)

Epsilon-(gamma-glutamyl)-lysine安全信息

Epsilon-(gamma-glutamyl)-lysine合成路线

详细合成路线

Epsilon-(gamma-glutamyl)-lysine文献

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