<生产厂家价格>

AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE

AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE用途

Autocamtide-2-related inhibitory peptide 是高度特异性的、CaMKII 的有效抑制剂,其IC50 值为 40 nM。

AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE名称

[ CAS 号 ]:
167114-91-2

[ 中文名 ]:
AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE

[ 英文名 ]:
Autocamtide-2-Related Inhibitory Peptide trifluoroacetate salt

[英文别名 ]:

AIP [Ala9]-Autocamtide 2
Autocamtide-2-related inhibitory peptide

AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE生物活性

[ 描述 ]:

Autocamtide-2-related inhibitory peptide 是高度特异性的、CaMKII 的有效抑制剂,其IC50 值为 40 nM。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 蛋白激酶

信号通路 >> 自噬 >> 自噬

研究领域 >> 神经疾病

[ 靶点 ]

IC50: 40 nM (CaMKII)[1].

[体外研究]

研究发现,Autocamtide-2相关抑制肽(一种新的合成肽ATP)是CaM激酶II的有效抑制剂,其IC50为40nm,在Ca2+/calmodulin存在或不存在时都具有活性。在所用的分析条件下,它的效力分别是CaMK-(281-302Ala286)和KN-93的50倍和500倍。

[参考文献]

[1]. Ishida A, et al. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem Biophys Res Commun. 1995 Jul 26;212(3):806-12.

AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE物理化学性质

[ 分子式 ]:
C₆₄H₁₁₆N₂₂O₁₉

[ 分子量 ]:
1822.12000

[ 精确质量 ]:
1821.07000

[ PSA ]:
746.43000

[ LogP ]:
8.46970

[ 外观性状 ]:
白色粉末

[ 储存条件 ]:
2-8°C，密封，干燥

AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
20/21/22-36

[ 安全声明 (欧洲) ]:
22-24/25-26

[ 危险品运输编码 ]:
NONH for all modes of transport

AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE文献

CaMKII Controls Whether Touch Is Painful.

J. Neurosci. 35 , 14086-102, (2015)

The sensation of touch is initiated when fast conducting low-threshold mechanoreceptors (Aβ-LTMRs) generate impulses at their terminals in the skin. Plasticity in this system is evident in the process...

Silanization-Based Zeolite Crystallization: Participation Degree and Pathway.

Chemistry 21 , 12161-70, (2015)

A clear and deep understanding of zeolite crystallization with the addition of organosilane is desirable for the reasonable design and preparation of hierarchical zeolites. Herein, the effects of diff...

Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII.

Cardiovasc. Res. 107 , 184-96, (2015)

Enhanced cardiac late Na current (late INa) and increased sarcoplasmic reticulum (SR)-Ca(2+)-leak are both highly arrhythmogenic. This study seeks to identify signalling pathways interconnecting late ...

更多文献