Temsirolimus (CCI-779)
Temsirolimus (CCI-779)用途
Temsirolimus (CCI-779)名称
[ CAS 号 ]:
162635-04-3
[ 中文名 ]:
西罗莫司脂化物
[ 英文名 ]:
Temsirolimus (CCI-779)
[中文别名 ]:
[英文别名 ]:
- CCL-779
- TeMsiroliMus (~)
- Torisel
- Temsirolimus
- [14C]-Temsirolimus
- TeMsiroliMus (Torisel)
- NSC 683864
Temsirolimus (CCI-779)生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
mTOR:1.76 μM (IC50)
[体外研究]
[体内研究]
[激酶实验]
[细胞实验]
[动物实验]
[参考文献]
[相关活性小分子]
Temsirolimus (CCI-779)物理化学性质
[ 密度 ]:
1.2±0.1 g/cm3
[ 沸点 ]:
1048.4±75.0 °C at 760 mmHg
[ 熔点 ]:
99-101ºC
[ 分子式 ]:
C56H87NO16
[ 分子量 ]:
1030.287
[ 闪点 ]:
587.8±37.1 °C
[ 精确质量 ]:
1029.602539
[ PSA ]:
241.96000
[ LogP ]:
2.96
[ 外观性状 ]:
white to off-white
[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C
[ 折射率 ]:
1.554
[ 储存条件 ]:
-20°C Freezer
[ 水溶解性 ]:
Soluble in chloroform, methanol.
Temsirolimus (CCI-779)安全信息
[ 安全声明 (欧洲) ]:
24/25
[ 危险品运输编码 ]:
NONH for all modes of transport
[ RTECS号 ]:
VE6257000
[ 海关编码 ]:
29349990
Temsirolimus (CCI-779)合成路线
Temsirolimus (CCI-779)上下游产品
Temsirolimus (CCI-779)上游产品
Temsirolimus (CCI-779)下游产品
Temsirolimus (CCI-779)文献
EMBO J. 34 , 1214-30, (2015)
Mammalian target of rapamycin (mTOR) is a key protein kinase that regulates cell growth, metabolism, and autophagy to maintain cellular homeostasis. Its activity is inhibited by adverse conditions, in...
Dual fatty acid synthase and HER2 signaling blockade shows marked antitumor activity against breast cancer models resistant to anti-HER2 drugs.PLoS ONE 10 , e0131241, (2015)
Blocking the enzyme Fatty Acid Synthase (FASN) leads to apoptosis of HER2-positive breast carcinoma cells. The hypothesis is that blocking FASN, in combination with anti-HER2 signaling agents, would b...
Dual blockade of PI3K/AKT/mTOR (NVP-BEZ235) and Ras/Raf/MEK (AZD6244) pathways synergistically inhibit growth of primary endometrioid endometrial carcinoma cultures, whereas NVP-BEZ235 reduces tumor growth in the corresponding xenograft models.Gynecol. Oncol. 138 , 165-73, (2015)
Endometrial carcinoma (EC) is the most common gynecological cancer in the Western World. Treatment options are limited for advanced and recurrent disease. Therefore, new treatment options are necessar...
相关化工产品/化学物质:
相关药品:
推荐生产厂家/供应商:
公司名:上海源溪生物科技有限公司
区域:上海市浦东新区
价格:
¥需询单/1g
联系人:赖经理
产品详情:Temsirolimus
公司名:上海脉铂医药科技有限公司
区域:上海市嘉定区
价格:
¥839.0/10mg
¥1139.0/1g
¥1779.0/25mg
¥2579.0/25mg
联系人:李先生
产品详情:Temsirolimus
公司名:上海创赛科技有限公司
区域:上海市嘉定区
价格:
¥562.0/10mg
¥833.0/10mg
¥需询单/1ml
¥1754.2/25mg
联系人:夏言
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥1441.9/25mg
¥411.9/5mg
¥989.9/1ml
¥4119.9/100mg
联系人:阿拉丁李高志
产品详情:替西罗莫司
公司名:湖北魏氏化学试剂股份有限公司
区域:武汉市洪山区
价格:
¥需询单/5mg
¥需询单/25mg
¥需询单/10g
¥需询单/50g
联系人:张栋
产品详情:坦西莫司(替西罗莫司
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相关化合物
[Temsirolimus (CCI-779)]化源网提供Temsirolimus (CCI-779)CAS号162635-04-3,Temsirolimus (CCI-779)MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询Temsirolimus (CCI-779)上化源网,专业又轻松。>>电脑版:Temsirolimus (CCI-779)
标题:【Temsirolimus (CCI-779)】Temsirolimus (CCI-779) CAS号:162635-04-3【结构式 性质 活性】-化源网 地址:https://www.chemsrc.com/amp/cas/162635-04-3_1026759.html