丁酰肼

丁酰肼用途

【用途一】
用作干果树生长的抑制剂，能抑制植物疯长
【用途二】
植物生长抑制剂。促进矮化，并能调整树干高度和观赏植物外形，而不影响开花影响。对作物有增加耐寒、耐旱能力，促进结实增产等效果。其作用机制是抑制内源生长素的合成。可用于果树、马铃薯、甘薯、番茄、草莓、菊花、人参等。国家农业部已撤销在花生上的登记。
【用途三】
丁酰肼能抑制植物生长，促进矮壮，而不影响开花结果。对作物有增加耐寒、耐旱能力、防止落花落果及促进结实增产等效果。
【用途四】
比久是一种生长抑制剂。它可抑制内源赤霉素的生物合成，也可抑制内源生长素的合成.

丁酰肼名称

[ CAS 号 ]:
1596-84-5

[ 中文名 ]:
丁酰肼

[ 英文名 ]:
Daminozide

[中文别名 ]:

[英文别名 ]:

B-Nine
Daminozide
4-(2,2-dimethylhydrazinyl)-4-oxobutanoic acid
Alar
KYLAR
sADH
succinic acid 2,2-dimethylhydrazide
(4E)-4-(Dimethylhydrazono)-4-hydroxybutanoic acid
4-(2,2-Dimethylhydrazino)-4-oxobutanoic acid
Succinic 2,2-dimethylhydrazide

丁酰肼生物活性

[ 描述 ]:

Daminozide(DMASA; DIMG; B 995)为植物生长调节剂,能选择性抑制KDM2/7 JmjC亚家族。

[ 相关类别 ]:

信号通路 >> 表观遗传学 >> 组蛋白去甲基化酶

研究领域 >> 癌症

[参考文献]

[1]. Rose NR, Woon EC, Tumber A, Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem. 2012 Jul 26;55(14):6639-43.

[2]. Schmiderer C, et al. Influence of gibberellin and daminozide on the expression of terpene synthases and on monoterpenes in common sage (Salvia officinalis). J Plant Physiol. 2010 Jul 1;167(10):779-86.

[3]. Reed DJ, Moore TC, Anderson JD. Plant Growth Retardant B-995: A Possible Mode of Action. Science. 1965 Jun 11;148(3676):1469-71.

[相关活性小分子]

丁酰肼物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
329.5±44.0 °C at 760 mmHg

[ 熔点 ]:
162-164 °C(lit.)

[ 分子式 ]:
C₆H₁₂N₂O₃

[ 分子量 ]:
160.171

[ 闪点 ]:
153.1±28.4 °C

[ 精确质量 ]:
160.084793

[ PSA ]:
69.64000

[ LogP ]:
-0.50

[ 外观性状 ]:
白色晶体粉末

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.497

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, strong acids, wetting agents, oils, copper-containing compounds.

[ 水溶解性 ]:
100 g/L

丁酰肼MSDS

详细MSDS(安全技术说明书)

丁酰肼毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WM9625000

CHEMICAL NAME :: Succinic acid, mono(2,2-dimethylhydrazide)

CAS REGISTRY NUMBER :: 1596-84-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C6-H12-N2-O3

MOLECULAR WEIGHT :: 160.20

WISWESSER LINE NOTATION :: QV2VMN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >147 gm/m3/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1325 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 8400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 182 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - uterine tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2600 gm/kg/62W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 873 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 156 mg/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 12,85,1988 *** REVIEWS *** TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 39,111,1977 TOXICOLOGY REVIEW FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,95,1979 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

丁酰肼安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R40

[ 安全声明 (欧洲) ]:
S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
WM9625000

[ 海关编码 ]:
2928000031

丁酰肼合成路线

详细合成路线

丁酰肼上下游产品

丁酰肼上游产品

丁酰肼下游产品

丁酰肼制备

以丁二酸为原料，先脱水制得丁二酸酐，再与偏二甲肼在乙腈中缩合而得。操作步骤是：将丁二酸一次投入反应釜，升温至215℃左右，开始脱水，直至釜温升至260℃左右，出水量达到理论量。在缩合釜中投入乙腈，再中入丁二酸酐，当料温控制在18℃时，慢慢滴加偏二甲肼，反应结束后，离心过滤、干燥得比久。

丁酰肼海关

[ 海关编码 ]: 2928000031

[ 中文概述 ]:
2928000031 抑食肼,虫酰肼,丁酰肼,联苯肼酯〔包括肟菌酯,苯氧菌胺〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: S.进出口农药登记证明

[ Summary ]:
2928000031 4-(2,2-dimethylhydrazinyl)-4-oxobutanoic acid。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

丁酰肼文献

Multiresidue analysis of plant growth regulators in grapes by triple quadrupole and quadrupole-time of flight-based liquid chromatography/mass spectrometry.

J. AOAC Int. 94(6) , 1715-21, (2011)

A selective and sensitive LC-MS/MS method is presented for simultaneous determination of 12 plant growth regulators, viz., indol-3-acetic acid, indol-3-butyric acid, kinetin, zeatin, 6-benzyl aminopur...

Lack of carcinogenicity of daminozide, alone or in combination with its contaminant 1,1-dimethylhydrazine, in a medium-term bioassay.

Teratog. Carcinog. Mutagen. 15(6) , 307-12, (1995)

The carcinogenicity of daminozide (succinic acid-2,2-dimethylhydrazide; Alar), a plant growth regulator used primarily in apple orchards, has been the subject of recent investigations by several natio...

Heterogeneous photocatalysed degradation of two selected pesticide derivatives, triclopyr and daminozid in aqueous suspensions of titanium dioxide.

J. Environ. Manage. 80(2) , 99-106, (2006)

Heterogeneous photocatalysed degradation of two selected pesticide derivatives, triclopyr (1) and daminozid (2), has been investigated in aqueous suspensions of titanium dioxide by monitoring the chan...

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丁酰肼