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rel-Tranylcypromine

rel-Tranylcypromine用途

rel-Tranylcypromine(SKF 385)是一种有效的单胺氧化酶(MAO)抑制剂[1]。

rel-Tranylcypromine名称

[ CAS 号 ]:
155-09-9

[ 中文名 ]:
SKF 385

[ 英文名 ]:
rel-Tranylcypromine

[英文别名 ]:

(1R,2S)-2-Phenylcyclopropanamine
2-Phenyl-1-aminocyclopropane, trans-
Tranylcypromine
Tranylcypromine (base and/or unspecified salts)
EINECS 205-841-9
(-)-Tranylcypromine
(1R,2S)-2-phenylcyclopropan-1-amine
Parnitene
SKF Trans-385
(1R)-2-Phenylcyclopropanamine

rel-Tranylcypromine生物活性

[ 描述 ]:

rel-Tranylcypromine(SKF 385)是一种有效的单胺氧化酶(MAO)抑制剂[1]。

[ 相关类别 ]:

研究领域 >> 心血管疾病

研究领域 >> 内分泌

信号通路 >> 神经信号通路 >> 单胺氧化酶

[体内研究]

瑞氨酰环丙胺(SKF 385)(0.1至3.0 mg/kg；静脉注射；杂种狗,体重5-10 kg)可升高血压。药物引起血压升高的程度和持续时间取决于给药剂量。当一次又一次地重复给予rel-Tranylcypromine时,通常会获得动物对rel-Tranylcypromine的降压反应[1]。

[参考文献]

[1]. TODA N, et al. The sympathomimetic effects of SKF-385 on blood pressure in dog. Jpn J Pharmacol. 1962;12:166-179.

rel-Tranylcypromine物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
218.3±29.0 °C at 760 mmHg

[ 分子式 ]:
C₉H₁₁N

[ 分子量 ]:
133.190

[ 闪点 ]:
90.8±19.6 °C

[ 精确质量 ]:
133.089142

[ PSA ]:
26.02000

[ LogP ]:
1.25

[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C

[ 折射率 ]:
1.584

[ 储存条件 ]:
2-8°C，密封，干燥

rel-Tranylcypromine毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GZ2450100

CHEMICAL NAME :: Cyclopropylamine, 2-phenyl-, trans-(+-)-

CAS REGISTRY NUMBER :: 155-09-9

BEILSTEIN REFERENCE NO. :: 3195803

LAST UPDATED :: 199803

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C9-H11-N

MOLECULAR WEIGHT :: 133.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 5714 ug/kg

TOXIC EFFECTS :: Cardiac - arrhythmias (including changes in conduction)

REFERENCE :: JATOD3 Journal of Analytical Toxicology. (Preston Pub. Inc., POB 48312, Niles, IL 60648) V.1- 1977- Volume(issue)/page/year: 20,301,1996

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 64 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 166,449,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - excitement

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,1727,1971

rel-Tranylcypromine安全信息

[ 海关编码 ]:
2921499090

rel-Tranylcypromine上下游产品

rel-Tranylcypromine上游产品

rel-Tranylcypromine下游产品

rel-Tranylcypromine海关

[ 海关编码 ]: 2921499090

[ 中文概述 ]:
2921499090 其他芳香单胺及衍生物及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%