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AB-MECA

AB-MECA用途

AB-MECA是一种高亲和性A3腺苷受体激动剂, 对重组A1和A3受体具有高亲和性。

AB-MECA名称

[ CAS 号 ]:
152918-26-8

[ 中文名 ]:
AB-MECA

[ 英文名 ]:
AB-MECA

[英文别名 ]:

N6-(4-Aminobenzyl)-N-methylcarboxamidoadenosine
[3H]AB-MECA
AB-MECA

AB-MECA生物活性

[ 描述 ]:

AB-MECA是一种高亲和性A3腺苷受体激动剂, 对重组A1和A3受体具有高亲和性。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体

研究领域 >> 神经疾病

[参考文献]

[1]. Shearman LP, et al. [125I]4-aminobenzyl-5'-N-methylcarboxamidoadenosine (125I)AB-MECA) labels multiple adenosine receptorsubtypes in rat brain. Brain Res. 1997 Jan 16;745(1-2):10-20.

[相关活性小分子]

AB-MECA物理化学性质

[ 密度 ]:
1.68g/cm3

[ 分子式 ]:
C₁₈H₂₁N₇O₄

[ 分子量 ]:
399.40400

[ 精确质量 ]:
399.16600

[ PSA ]:
163.93000

[ LogP ]:
0.88030

[ 折射率 ]:
1.789

[ 储存条件 ]:
2-8℃

AB-MECAMSDS

详细MSDS(安全技术说明书)

AB-MECA安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

AB-MECA文献

125I-4-aminobenzyl-5'-N-methylcarboxamidoadenosine, a high affinity radioligand for the rat A3 adenosine receptor.

Mol. Pharmacol. 45 , 978-982, (1994)

The rat A3 adenosine receptor (AR) is a recently characterized AR subtype cloned from testis and brain cDNA libraries. N6-2-(4-Amino-3-[125I]iodophenyl)ethyladenosine, a high affinity A1AR agonist, ha...

A role for central A3-adenosine receptors. Mediation of behavioral depressant effects.

FEBS Lett. 336 , 57-60, (1993)

The behavioral effects of a selective A3 adenosine receptor agonist 3-IB-MECA (N6-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine) in mice and the localization of radioligand binding sites in mouse bra...

Structure-activity relationships of N6-benzyladenosine-5'-uronamides as A3-selective adenosine agonists.

J. Med. Chem. 37 , 636-646, (1994)

Adenosine analogues modified at the 5'-position as uronamides and/or as N6-benzyl derivatives were synthesized. These derivatives were examined for affinity in radioligand binding assays at the newly ...

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