托吡卡胺
托吡卡胺用途
托吡卡胺名称
[ CAS 号 ]:
1508-75-4
[ 中文名 ]:
托吡卡胺
[ 英文名 ]:
Tropicamide
[中文别名 ]:
[英文别名 ]:
- N-Ethyl-N-(g-picolyl)tropamide
- 8-Methyl-8-azabicyclo[3.2.1]octan-3-ol
- N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide
- Tropine
- endo-Tropanol
- TROPAN-3ALPHA-OL
- 3alpha-Tropanol
- 8-Azabicyclo[3.2.1]octan-3-ol, 8-methyl-
- N-Ethyl-N-(4-pyridylmethyl)tropamide
- EINECS 216-140-2
托吡卡胺生物活性
[ 描述 ]:
[ 相关类别 ]:
[参考文献]
[相关活性小分子]
托吡卡胺物理化学性质
[ 密度 ]:
1.2±0.1 g/cm3
[ 沸点 ]:
492.8±45.0 °C at 760 mmHg
[ 熔点 ]:
98 °C
[ 分子式 ]:
C17H20N2O2
[ 分子量 ]:
284.353
[ 闪点 ]:
251.8±28.7 °C
[ 精确质量 ]:
284.152466
[ PSA ]:
53.43000
[ LogP ]:
1.15
[ 外观性状 ]:
白色粉末
[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C
[ 折射率 ]:
1.586
[ 储存条件 ]:
2-8°C
[ 水溶解性 ]:
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 4.3 mg/mL
托吡卡胺MSDS
托吡卡胺毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CY1487860
- CHEMICAL NAME :
- Benzeneacetamide, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)-
- CAS REGISTRY NUMBER :
- 1508-75-4
- BEILSTEIN REFERENCE NO. :
- 0285563
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C17-H20-N2-O2
- MOLECULAR WEIGHT :
- 284.39
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 865 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,760,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1210 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,760,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 872 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,760,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 565 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,760,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 695 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,760,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 665 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,760,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2832 No. of Facilities: 112 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4368 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2832 No. of Facilities: 29 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 11614 (estimated) No. of Female Employees: 11545 (estimated)
托吡卡胺安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302 + H312 + H332-H315-H317-H319-H335
[ 警示性声明 ]:
P261-P280-P301 + P312 + P330-P305 + P351 + P338
[ 危害码 (欧洲) ]:
Xn:Harmful
[ 风险声明 (欧洲) ]:
R20/21/22;R36/37/38;R42/43
[ 安全声明 (欧洲) ]:
S22-S26-S36
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
3
[ RTECS号 ]:
CY1487860
[ 海关编码 ]:
2933399090
托吡卡胺合成路线
托吡卡胺上下游产品
托吡卡胺上游产品
托吡卡胺下游产品
托吡卡胺海关
[ 海关编码 ]: 2933399090
[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
托吡卡胺文献
Ophthalmic Res. 53(2) , 65-73, (2015)
The purpose of this study was to evaluate the effect of pulse duration on the expression of inflammatory cytokines in the murine retina after laser photocoagulation treatment with a PASCAL(®) pattern ...
Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids.Biochim. Biophys. Acta 1851(3) , 290-8, (2015)
We recently demonstrated that 12/15-lipoxygenase (LOX) derived metabolites, hydroxyeicosatetraenoic acids (HETEs), contribute to diabetic retinopathy (DR) via NADPH oxidase (NOX) and disruption of the...
Protective Effects of Human iPS-Derived Retinal Pigmented Epithelial Cells in Comparison with Human Mesenchymal Stromal Cells and Human Neural Stem Cells on the Degenerating Retina in rd1 mice.Stem Cells 33(5) , 1543-53, (2015)
Retinitis pigmentosa (RP) is a group of visual impairments characterized by progressive rod photoreceptor cell loss due to a genetic background. Pigment epithelium-derived factor (PEDF) predominantly ...
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相关药品:
推荐生产厂家/供应商:
公司名:上海吉至生化科技有限公司
区域:上海市奉贤区
价格:
¥758.0/5g
¥198.0/1g
联系人:刘佳
产品详情:托吡卡胺
公司名:上海源溪生物科技有限公司
区域:上海市浦东新区
价格:
¥需询单/1g
联系人:赖经理
产品详情:Tropicamide
公司名:上海脉铂医药科技有限公司
区域:上海市嘉定区
价格:
¥749.0/500mg
¥519.0/100mg
¥489.0/1g
¥需询单/1g
联系人:李先生
产品详情:Tropicamide
公司名:上海创赛科技有限公司
区域:上海市嘉定区
价格:
¥1453.0/25g
¥160.0/1g
¥394.0/5g
¥744.8/500mg
联系人:夏言
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥56.9/1g
¥195.9/5g
¥453.9/1ml
¥865.9/25g
联系人:阿拉丁李高志
产品详情:托吡卡胺
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相关化合物
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标题:托吡卡胺_MSDS_用途_密度_托吡卡胺CAS号【1508-75-4】_化源网 地址:https://www.chemsrc.com/amp/cas/1508-75-4_1150762.html