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培氟沙星

培氟沙星用途

去水甲磺酸Pefloxacin是抗菌素,能通过抑制DNA旋转酶阻断细菌DNA复制。

培氟沙星名称

[ CAS 号 ]:
149676-40-4

[ 中文名 ]:
培氟沙星

[ 英文名 ]:
Pefloxacin mesylate dihydrate

[中文别名 ]:

盐酸地布卡因

[英文别名 ]:

MFCD01685696
EINECS 274-613-9
Pefloxacin mesilate dihydrate

培氟沙星生物活性

[ 描述 ]:

去水甲磺酸Pefloxacin是抗菌素,能通过抑制DNA旋转酶阻断细菌DNA复制。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. Drlica K, et al. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92.

[2]. Hussy P, et al. Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts. Antimicrob Agents Chemother. 1986 Jun;29(6):1073-8.

[相关活性小分子]

培氟沙星物理化学性质

[ 沸点 ]:
529.1ºC at 760mmHg

[ 熔点 ]:
271ºC

[ 分子式 ]:
C₁₈H₂₈FN₃O₈S

[ 分子量 ]:
465.49400

[ 闪点 ]:
273.8ºC

[ 精确质量 ]:
465.15800

[ PSA ]:
146.99000

[ LogP ]:
2.06960

[ 外观性状 ]:
白色粉末

[ 储存条件 ]:
Store at?0-5°C

培氟沙星安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22-36

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
VB2002200

培氟沙星文献

Pefloxacin-induced achilles tendon toxicity in rodents: biochemical changes in proteoglycan synthesis and oxidative damage to collagen.

Antimicrob. Agents Chemother. 44 , 867-872, (2000)

Despite a relatively low incidence of serious side effects, fluoroquinolones and the fluoroquinolone pefloxacin have been reported to occasionally promote tendinopathy that might result in the complic...

Cytotoxicity and uptake of pefloxacin, ciprofloxacin, and ofloxacin in primary cultures of rat hepatocytes.

J. Antimicrob. Chemother. 24 , 355-363, (1989)

The cytotoxicity and the uptake of three 4-quinolones--pefloxacin, ciprofloxacin, and ofloxacin--were investigated in primary cultures of rat hepatocytes. As assessed by intracellular enzyme release i...

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