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普瑞巴林

普瑞巴林用途

该药是在开发的癫痫治疗药中最有希望的一个药物，疗效更好和给药更方便。也可以用于治疗疼痛和焦虑。

普瑞巴林名称

[ CAS 号 ]:
148553-50-8

[ 中文名 ]:
普瑞巴林

[ 英文名 ]:
Pregabalin

[中文别名 ]:

[英文别名 ]:

(S)-3-Aminomethyl-5-methyl-hexanoic acid
EINECS 200-659-6
PREDNISOLONESODIUMPHOSPHATE
Hexanoic acid, 3-(aminomethyl)-5-methyl-, (3S)-
Pregablin
(S)-3-(Aminomethyl)-5-methylhexanoic acid
Pregabalin
Lyrica
prégabaline
(S)-3-Isobutyl GABA

普瑞巴林物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
274.0±23.0 °C at 760 mmHg

[ 熔点 ]:
194-196ºC

[ 分子式 ]:
C₈H₁₇NO₂

[ 分子量 ]:
159.226

[ 闪点 ]:
119.5±22.6 °C

[ 精确质量 ]:
159.125931

[ PSA ]:
63.32000

[ LogP ]:
1.12

[ 外观性状 ]:
白色或近乎于白色结晶粉末

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.465

[ 储存条件 ]:
Store at RT

普瑞巴林安全信息

[ 符号 ]:

GHS05, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H318-H361

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn,T,F

[ 风险声明 (欧洲) ]:
63-48/22-39/23/24/25-23/24/25-11

[ 安全声明 (欧洲) ]:
22-36/37-45-16-7

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2915900090

普瑞巴林合成路线

详细合成路线

普瑞巴林上下游产品

普瑞巴林上游产品

普瑞巴林下游产品

普瑞巴林海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

普瑞巴林文献

Development of a SPE-HPLC-MS/MS method for the determination of most prescribed pharmaceuticals and related metabolites in urban sewage samples.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 990 , 23-30, (2015)

Based on regional prescription data several pharmaceuticals with variable amounts of prescription and corresponding metabolites were selected and analyzed in influent and effluent samples of the sewag...

Effect of the gastrointestinal prokinetic agent erythromycin on the pharmacokinetics of pregabalin controlled-release in healthy individuals: a phase I, randomized crossover trial.

Clin. Drug Investig. 35(5) , 299-305, (2015)

The controlled-release (CR) formulation of pregabalin is designed to remain in the stomach for a prolonged period while slowly releasing pregabalin for absorption in the small intestine. This study ev...

Evaluation of the matrix effect of different sample matrices for 33 pharmaceuticals by post-column infusion.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1000 , 84-94, (2015)

Matrix effects that occur during quantitative measurement by liquid chromatography mass spectrometry specifically when using electrospray ionization are a widely recognized phenomenon. Sample matrix c...

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