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碘代乙酰胺

碘代乙酰胺用途

2-Iodoacetamide (Iodoacetamide) 是一种常用的烷基化剂,常用于蛋白质组学样品制备过程中半胱氨酸烷基化。

碘代乙酰胺名称

[ CAS 号 ]:
144-48-9

[ 中文名 ]:
2-碘乙酰胺

[ 英文名 ]:
Iodoacetamide

[中文别名 ]:

[英文别名 ]:

MFCD00008028
carbamoylmethyl iodide
2-Iodo-acetamide
USAF D-1
Monoiodoacetamide
2-iodoacetamido
Acetamide, 2-iodo-
Iodoacetamide
ACETAMIDE,2-IODO
2-Iodoacetamide

碘代乙酰胺生物活性

[ 描述 ]:

2-Iodoacetamide (Iodoacetamide) 是一种常用的烷基化剂,常用于蛋白质组学样品制备过程中半胱氨酸烷基化。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体内研究]

2-碘乙酸(2.0-10 mg；饮酒；每天；20-93天)喂养总是在大鼠胃的分泌部分产生慢性深溃疡[2]。动物模型：Sprague-Dawley大鼠[2]剂量：2.0-10 mg给药：饮用水,每日,持续20-93天。结果：在许多试验大鼠中产生胃炎,并进一步并发慢性溃疡。

[参考文献]

[1]. Peter G Hains, et al. The Impact of Commonly Used Alkylating Agents on Artifactual Peptide Modification. J Proteome Resq. 2017 Sep 1;16(9):3443-3447.

[2]. J J LALICH. Iodoacetamide induced gastric ulcers in rats. Proc Soc Exp Biol Med. 1962 Apr;109:905-8.

碘代乙酰胺物理化学性质

[ 密度 ]:
2.3±0.1 g/cm3

[ 沸点 ]:
297.1±23.0 °C at 760 mmHg

[ 熔点 ]:
92-95 °C(lit.)

[ 分子式 ]:
C₂H₄INO

[ 分子量 ]:
184.964

[ 闪点 ]:
133.5±22.6 °C

[ 精确质量 ]:
184.933746

[ PSA ]:
43.09000

[ LogP ]:
-0.19

[ 外观性状 ]:
结晶

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.602

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable, but light sensitive. Incompatible with strong oxidizing agents, strong bases, reducing agents, acids.

[ 水溶解性 ]:
slightly soluble

碘代乙酰胺MSDS

碘代乙酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC4200000

CHEMICAL NAME :: Acetamide, 2-iodo-

CAS REGISTRY NUMBER :: 144-48-9

BEILSTEIN REFERENCE NO. :: 1739080

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C2-H4-I-N-O

MOLECULAR WEIGHT :: 184.97

WISWESSER LINE NOTATION :: ZV1I

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 74 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1480 mg/kg/20W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 umol/L

REFERENCE :: STBIBN Studia Biophysica. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086, Ger. Dem. Rep.) V.1- 1966- Volume(issue)/page/year: 50,97,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4435 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)

碘代乙酰胺安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H317-H334-H413

[ 警示性声明 ]:
P261-P280-P301 + P310-P342 + P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R25;R36/37/38;R43

[ 安全声明 (欧洲) ]:
S22-S36/37-S45-S37/39-S26-S24

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
AC4200000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2924199090

碘代乙酰胺合成路线

碘代乙酰胺上下游产品

碘代乙酰胺上游产品

碘代乙酰胺下游产品

碘代乙酰胺制备

由氯乙酰胺与碘化钠反应而得。将氯乙酰胺、无水丙酮、无水碘化钠在浴上回流15h。冷至室温，滤出氯化钠，回收丙酮，稍冷后倒入硫酸氢钠的冰水中，然后用硫酸钠饱和溶液中和至pH6。冷却结晶，过滤得粗品。粗品用水重结晶，即得成品。

碘代乙酰胺海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

碘代乙酰胺文献

A new enabling proteomics methodology to investigate membrane associated proteins from parasitic nematodes: case study using ivermectin resistant and ivermectin susceptible isolates of Caenorhabditis elegans and Haemonchus contortus.

Vet. Parasitol. 207(3-4) , 266-75, (2015)

The mechanisms involved in anthelmintic resistance (AR) are complex but a greater understanding of AR management is essential for effective and sustainable control of parasitic helminth worms in lives...

Rad23 interaction with the proteasome is regulated by phosphorylation of its ubiquitin-like (UbL) domain.

J. Mol. Biol. 426(24) , 4049-60, (2014)

Rad23 was identified as a DNA repair protein, although a role in protein degradation has been described. The protein degradation function of Rad23 contributes to cell cycle progression, stress respons...

Proteomic analysis of nasal epithelial cells from cystic fibrosis patients.

PLoS ONE 9(9) , e108671, (2014)

The pathophysiology of cystic fibrosis (CF) lung disease remains incompletely understood. New explanations for the pathogenesis of CF lung disease may be discovered by studying the patterns of protein...

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