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U-73343

U-73343用途

U-73343 是 PLC 依赖过程的抑制剂,是U-73122的一种类似物,可作为一种阴性对照。

U-73343名称

[ CAS 号 ]:
142878-12-4

[ 中文名 ]:
1-[6-[((17Β)-3-METHOXYESTRA-1,3,5[10]-TRIEN-17-YL)AMINO]HEXYL]-2,5-PYRROLIDINEDIONE

[ 英文名 ]:
U-73343

[英文别名 ]:

MFCD00211221
IN1024

U-73343生物活性

[ 描述 ]:

U-73343 是 PLC 依赖过程的抑制剂,是U-73122的一种类似物,可作为一种阴性对照。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 磷脂

研究领域 >> 其他

[参考文献]

[1]. Muto Y, et al. The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell. J Pharmacol Exp Ther. 1997 Sep;282(3):1379-88.

U-73343物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
641.5±55.0 °C at 760 mmHg

[ 分子式 ]:
C₂₉H₄₂N₂O₃

[ 分子量 ]:
466.66

[ 闪点 ]:
341.8±31.5 °C

[ 精确质量 ]:
466.319550

[ PSA ]:
58.64000

[ LogP ]:
5.49

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.578

[ 储存条件 ]:
2-8°C

U-73343MSDS

详细MSDS(安全技术说明书)

U-73343安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

U-73343文献

Mechanisms of the sarcoplasmic reticulum Ca2+ release induced by P2X receptor activation in mesenteric artery myocytes.

Pharmacol. Rep. 66(3) , 363-72, (2014)

ATP is one of the principal sympathetic neurotransmitters which contracts vascular smooth muscle cells (SMCs) via activation of ionotropic P2X receptors (P2XRs). We have recently demonstrated that con...

G protein-coupled receptor signalling potentiates the osmo-mechanical activation of TRPC5 channels.

Pflugers Arch. 466(8) , 1635-46, (2014)

TRPC5 is an ion channel permeable to monovalent and divalent cations that is widely expressed in different tissues. Although implicated in the control of neurite extension and in the growth cone morph...

Brain phospholipase C/diacylglycerol lipase are involved in bombesin BB2 receptor-mediated activation of sympatho-adrenomedullary outflow in rats.

Eur. J. Pharmacol. 514(2-3) , 151-8, (2005)

Bombesin receptors are mainly divided into two subtypes: BB1 receptor (neuromedin B-preferring receptor) and BB2 receptor [gastrin-releasing peptide (GRP)-preferring receptor]. Previously, we reported...

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