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S-苄基硫脲盐酸盐

S-苄基硫脲盐酸盐用途

【用途一】
有机合成中间体，分析试剂。
【用途二】
测定钴和镍的试剂，鉴别和分离羧酸、亚磺酸及磺酸，有机微量分析测定氮、硫和氯的标准样品。有机合成中间体。

S-苄基硫脲盐酸盐名称

[ CAS 号 ]:
538-28-3

[ 中文名 ]:
S-苄基异硫脲盐酸盐

[ 英文名 ]:
U 19451A

[中文别名 ]:

[英文别名 ]:

btkh
usafek-2124
Pseudourea, 2-benzyl-2-thio-, monohydrochloride
MFCD00012583
benzylthiouronium chloride
S-Benzylthiopseudourea hydrochloride
2-Benzyl-2-thiopseudourea Hydrochloride
Pseudourea, 2-benzyl-2-thio-, hydrochloride
S-Benzylisothiourea hydrochloride
tl944

S-苄基硫脲盐酸盐物理化学性质

[ 沸点 ]:
283.2ºC at 760mmHg

[ 熔点 ]:
172-177 °C

[ 分子式 ]:
C₈H₁₁ClN₂S

[ 分子量 ]:
202.704

[ 闪点 ]:
125.1ºC

[ 精确质量 ]:
202.033142

[ PSA ]:
75.17000

[ LogP ]:
3.41530

[ 外观性状 ]:
白色晶体和块

[ 储存条件 ]:
通风低温干燥,与库房食品原料分开存放

[ 水溶解性 ]:
250 g/L (15 ºC)

S-苄基硫脲盐酸盐MSDS

S-苄基硫脲盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UM0738000

CHEMICAL NAME :: Pseudourea, 2-benzyl-2-thio-, monohydrochloride

CAS REGISTRY NUMBER :: 538-28-3

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C8-H10-N2-S.Cl-H

MOLECULAR WEIGHT :: 202.72

WISWESSER LINE NOTATION :: MUYZS1R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 27 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 27(2),52,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: URXXAF U.S.S.R. Patent Document. (Gosudarstvennyi Komitet SSSR po Delam Izobretenii i Otkrytii, Malyi Tcherkasski pereulok 2/6, Moscow, Russia). Volume(issue)/page/year: #0822829

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report. Volume(issue)/page/year: No.9-4-1-9,1943

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00167

S-苄基硫脲盐酸盐安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300

[ 警示性声明 ]:
P264-P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R25

[ 安全声明 (欧洲) ]:
S36/37/39-S45-S28A

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
UM0738000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29309070

S-苄基硫脲盐酸盐合成路线

S-苄基硫脲盐酸盐制备

由氯苄与硫脲缩合而得。将氯苄、硫脲和乙醇加入反应器中混合，加热回流，反应后脱色过滤，冷却结晶，再用乙醚洗涤，精制而得成品。

S-苄基硫脲盐酸盐海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

S-苄基硫脲盐酸盐文献

S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase.

Bioorg. Med. Chem. Lett. 20 , 5126-9, (2010)

S-benzylisothiourea 3a was discovered by its ability to inhibit indoleamine-2,3-dioxygenase (IDO) in our screening program. Subsequent optimization of the initial hit 3a lead to the identification of ...

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