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2,3-双(4-羟苯基)丙腈

2,3-双(4-羟苯基)丙腈用途

Diarylpropionitrile(DPN)是一种非甾体雌激素受体(ER_beta_)选择性配体。

2,3-双(4-羟苯基)丙腈名称

[ CAS 号 ]:
1428-67-7

[ 中文名 ]:
2,3-双(4-羟苯基)丙腈

[ 英文名 ]:
2,3-bis(4-hydroxyphenyl)propionitrile

[英文别名 ]:

2,3-bis(4-hydroxyphenyl)propionitrile
DPN Diarylpropionitrile SC-4473
2,3-Bis(4-hydroxyphenyl)propanenitrile
DPN

2,3-双(4-羟苯基)丙腈生物活性

[ 描述 ]:

Diarylpropionitrile(DPN)是一种非甾体雌激素受体(ER_beta_)选择性配体。

[ 相关类别 ]:

信号通路 >> 其他 >> 雌激素受体/ERR

研究领域 >> 神经疾病

[参考文献]

[1]. Suwanna N, et al. Neuroprotective effects of diarylpropionitrile against β-amyloid peptide-induced neurotoxicity in rat cultured cortical neurons. Neurosci Lett. 2014 Aug 22;578:44-9.

[2]. Khalaj AJ, et al. Estrogen receptor (ER) β expression in oligodendrocytes is required for attenuation of clinical disease by an ERβ ligand. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19125-30.

[3]. Huang SY, et al. Estrogen receptor β agonist diarylpropionitrile inhibits lipopolysaccharide-induced regulated on activation normal T cell expressed and secreted (RANTES) production in macrophages by repressing nuclear factor κB activation. Fertil Steril.

[相关活性小分子]

2,3-双(4-羟苯基)丙腈物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
449.4±35.0 °C at 760 mmHg

[ 熔点 ]:
203°C

[ 分子式 ]:
C₁₅H₁₃NO₂

[ 分子量 ]:
239.269

[ 闪点 ]:
225.6±25.9 °C

[ 精确质量 ]:
239.094635

[ PSA ]:
64.25000

[ LogP ]:
2.06

[ 外观性状 ]:
灰白色固体

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.640

[ 储存条件 ]:
-20°C

2,3-双(4-羟苯基)丙腈MSDS

详细MSDS(安全技术说明书)

2,3-双(4-羟苯基)丙腈毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UG0900000

CHEMICAL NAME :: Propionitrile, 2,3-bis(p-hydroxyphenyl)

CAS REGISTRY NUMBER :: 1428-67-7

BEILSTEIN REFERENCE NO. :: 3337109

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C15-H13-N-O2

MOLECULAR WEIGHT :: 239.29

WISWESSER LINE NOTATION :: QR DYCN&1R DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - muscle weakness Behavioral - ataxia

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 112,176,1954

2,3-双(4-羟苯基)丙腈安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319-H400

[ 警示性声明 ]:
P273-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

2,3-双(4-羟苯基)丙腈合成路线

详细合成路线

2,3-双(4-羟苯基)丙腈上下游产品

2,3-双(4-羟苯基)丙腈上游产品

2,3-双(4-羟苯基)丙腈下游产品

2,3-双(4-羟苯基)丙腈文献

A precisely substituted benzopyran targets androgen refractory prostate cancer cells through selective modulation of estrogen receptors.

Toxicol. Appl. Pharmacol. 283(3) , 187-97, (2015)

Dietary consumption of phytoestrogens like genistein has been linked with lower incidence of prostate cancer. The estradiol-like benzopyran core of genistein confers estrogen receptor-β (ER-β) selecti...

Classical and membrane-initiated estrogen signaling in an in vitro model of anterior hypothalamic kisspeptin neurons.

Endocrinology 156 , 2162-73, (2015)

The neuropeptide kisspeptin is essential for sexual maturation and reproductive function. In particular, kisspeptin-expressing neurons in the anterior rostral periventricular area of the third ventric...

Methyltransferase-like 17 physically and functionally interacts with estrogen receptors.

IUBMB Life 67 , 861-8, (2016)

Estrogen exerts its physiological and pathological functions through two estrogen receptors (ERs), ERα and ERβ, which act as transcription factors. Coregulators, including coactivators and corepressor...

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