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L-701324

L-701324用途

L-701324是一种具有口服活性的, 长效抗惊厥剂, 对NMDA受体的甘氨酸位点具有高亲和力和选择性。

L-701324名称

[ CAS 号 ]:
142326-59-8

[ 中文名 ]:
7-氯-4-羟基-3-(3-苯氧基)苯基-2(1H)-喹啉

[ 英文名 ]:
L 701324

[英文别名 ]:

7-chloro-3-(3-phenoxyphenyl)quinoline-2,4-diol
Sulprostone
2,4-quinolinediol, 7-chloro-3-(3-phenoxyphenyl)-
L-701,324
L-701324

L-701324生物活性

[ 描述 ]:

L-701324是一种具有口服活性的, 长效抗惊厥剂, 对NMDA受体的甘氨酸位点具有高亲和力和选择性。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> iGluR

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

[参考文献]

[1]. Piotr Wlaz, et al. Differential effects of glycine on the anticonvulsant activity of D-cycloserine and L-701,324 in mice. Pharmacological Reports 2011,63,1231-1234

[相关活性小分子]

L-701324物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
584.7±50.0 °C at 760 mmHg

[ 分子式 ]:
C₂₁H₁₄ClNO₃

[ 分子量 ]:
363.794

[ 闪点 ]:
307.4±30.1 °C

[ 精确质量 ]:
363.066223

[ PSA ]:
62.32000

[ LogP ]:
5.50

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.680

[ 储存条件 ]:
2-8℃

L-701324MSDS

详细MSDS(安全技术说明书)

L-701324安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

L-701324文献

NMDA/glutamate mechanism of magnesium-induced anxiolytic-like behavior in mice.

Pharmacol. Rep. 60(5) , 655-63, (2008)

The anxiolytic-like activity of magnesium in mice during the elevated plus maze (EPM) has been demonstrated previously. In the present study, we examined the involvement of NMDA/glutamate receptor lig...

NMDA/glutamate mechanism of antidepressant-like action of magnesium in forced swim test in mice.

Pharmacol. Biochem. Behav. 88(2) , 158-64, (2007)

Antidepressant-like activity of magnesium in forced swim test (FST) was demonstrated previously. Also, enhancement of such activity by joint administration of magnesium and antidepressants was shown. ...

Activation of the NMDA/glutamate receptor complex antagonizes the NMDA antagonist-induced antidepressant-like effects in the forced swim test.

Pharmacol. Rep. 59(5) , 595-600, (2007)

The antidepressant activity of NMDA receptor antagonists has been demonstrated, and their mechanism of action was based on the assumption of their selectivity for the NMDA receptor only. However, no d...

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