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3-疏基丙酰基-beta-3-吡啶-d-ala-phe-gln-asn-cys-pro-arg-gly-nh2

用途

去氨基(D-3-(3′-吡啶基)-Ala2,Arg8)-加压素,一种加压素(AVP)的合成类似物,是抗利尿受体的弱激动剂。然而,去氨基(D-3-(3′-吡啶基)-Ala2,Arg8)-加压素是垂体促肾上腺皮质激素受体的有效激动剂[1]。

名称

[ CAS 号 ]:
136105-89-0

[ 中文名 ]:
3-疏基丙酰基-beta-3-吡啶-d-ala-phe-gln-asn-cys-pro-arg-gly-nh2

[ 英文名 ]:
(Deamino-Cys1,β-(3-pyridyl)-D-Ala2,Arg8)-Vasopressin trifluoroacetate salt

[中文别名 ]:

[英文别名 ]:

生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管加压素受体

[ 靶点 ]

Antidiuretic receptor; Pituitary corticotrope receptor[1]

[体外研究]

去氨基(D-3-(3′-吡啶基)-Ala2,Arg8)-加压素(1 nM-10μM)对绵羊离体绵羊垂体前叶细胞有促肾上腺皮质激素释放活性[1]。

[体内研究]

去氨基(D-3-(3′-吡啶基)-Ala2,Arg8)-加压素(50μg/羊；静脉注射; 单剂量) 显示促肾上腺皮质激素释放活性[1]。

[参考文献]

[1]. Schwartz J, et al. A potent new synthetic analog of vasopressin with relative agonist specificity for the pituitary. Endocrinology. 1991 Aug;129(2):1107-9.

物理化学性质

[ 密度 ]:
1.56g/cm3

[ 分子式 ]:
C₄₅H₆₃N₁₅O₁₁S₂

[ 分子量 ]:
1054.21000

[ 精确质量 ]:
1053.43000

[ PSA ]:
478.67000

[ LogP ]:
1.21290

[ 折射率 ]:
1.716

安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H332

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
NONH for all modes of transport

文献

Arginine vasopressin enhances pHi regulation in the presence of HCO3- by stimulating three acid-base transport systems.

Nature 337(6208) , 648-51, (1989)

Growth factors raise intracellular pH (pHi) by stimulating Na+/H+ exchange in the absence of HCO3-. In mutant cells that lack the Na+/H+ exchange activity, this alkalinization does not occur, and the ...

Arginine vasopressin in advanced vasodilatory shock: a prospective, randomized, controlled study.

Circulation 107(18) , 2313-9, (2003)

Vasodilatory shock is a potentially lethal complication of severe disease in critically ill patients. Currently, catecholamines are the most widely used vasopressor agents to support blood pressure, b...

Regulation of cyclooxygenase expression by vasopressin in rat renal medulla.

Endocrinology 145(3) , 1402-9, (2004)

The antagonism between prostaglandin and vasopressin represents a classic negative feedback loop. It is not clear whether cyclooxygenase (COX)-2 and/or COX-1 expression is involved in elevated prostag...

更多文献

3-疏基丙酰基-beta-3-吡啶-d-ala-phe-gln-asn-cys-pro-arg-gly-nh2

用途

名称

生物活性

物理化学性质

安全信息

文献

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