ARQ092盐酸盐

Miransertib, also known as ARQ 092, is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3). ARQ 092 binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway. This may lead to the reduction in tumor cell proliferation and the induction of tumor cell apoptosis. ARQ-092 demonstrated high enzymatic potency against AKT1, AKT2, and AKT3, as well as potent cellular inhibition of AKT activation and the phosphorylation of the downstream target PRAS40. ARQ-092 also served as a potent inhibitor of the AKT1-E17K mutant protein and inhibited tumor growth in a human xenograft mouse model of endometrial adenocarcinoma.

[ 分子式 ]:
C₂₇H₂₅ClN₆

[ 分子量 ]:
468.981

[ 精确质量 ]:
468.182922

[ 外观性状 ]:
粉末

[ 储存条件 ]:
-20℃

公司名：上海化源生化科技有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：3-(3-(4-(1-氨基环丁基)苯基)-5-苯基-3H-咪唑并[45-b]吡啶-2-基)吡啶-2-胺盐酸盐

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公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：Miransertib HCl

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥1174.9/10mg ￥715.9/5mg ￥1005.9/1ml ￥5149.9/100mg

联系人：阿拉丁

产品详情：Miransertib hydrochloride

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