腺苷2'(3')-单磷酸盐混合异构体

腺苷2'(3')-单磷酸盐混合异构体用途

Adenosine-2'-monophosphate (2'-AMP) 是由细胞外 2’,3'-CAMP 转化的。Adenosine-2'-monophosphate 进一步代谢为细胞外腺苷 (由一种称为细胞外2',3'-环腺苷酸途径的机制)。Adenosine-2'-monophosphate 通过激活 A2A 受体抑制 LPS 诱导的TNF-α 和 CXCL10 的产生。

腺苷2'(3')-单磷酸盐混合异构体名称

[ CAS 号 ]:
130-49-4

[ 中文名 ]:
腺苷酸2(3)-磷酸

[ 英文名 ]:
Adenosine-2'-monophosphate

[中文别名 ]:

[英文别名 ]:

MFCD00151215
Adenosine 2'-monophosphate
Methionyl adenylate
adenosine 2'-monophosphoric acid
Adenosine 2'(3')-monophosphate mixed isomers
Adenosine 2'-phosphate
Methioninyl adenylate
2'-Adenylic acid
EINECS 204-990-7
L-METHIONYL ADENYLATE

腺苷2'(3')-单磷酸盐混合异构体生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体

[ 靶点 ]

Human Endogenous Metabolite

A2A adenosine receptor

A2B adenosine receptor

[体外研究]

腺苷-2'-单磷酸(2'-AMP)(0-100μM；每天4天)通过A2B受体抑制肾小球前血管平滑肌细胞和肾小球系膜细胞的增殖[1]。腺苷-2'-单磷酸(30μM；24小时)抑制LPS诱导的(100 ng/ml)小鼠原代小胶质细胞产生TNF-α和CXCL10[1]。

[参考文献]

[1]. Jackson EK, Gillespie DG, Dubey RK. 2'-AMP and 3'-AMP inhibit proliferation of preglomerular vascular smooth muscle cells and glomerular mesangial cells via A2B receptors. J Pharmacol Exp Ther. 2011;337(2):444‐450.

[2]. Newell EA, Exo JL, Verrier JD, et al. 2',3'-cAMP, 3'-AMP, 2'-AMP and adenosine inhibit TNF-α and CXCL10 production from activated primary murine microglia via A2A receptors. Brain Res. 2015;1594:27‐35.

腺苷2'(3')-单磷酸盐混合异构体物理化学性质

[ 密度 ]:
2.3±0.1 g/cm3

[ 沸点 ]:
815.5±75.0 °C at 760 mmHg

[ 分子式 ]:
C₁₀H₁₄N₅O₇P

[ 分子量 ]:
347.221

[ 闪点 ]:
447.0±37.1 °C

[ 精确质量 ]:
347.063080

[ PSA ]:
195.88000

[ LogP ]:
-1.74

[ 蒸汽压 ]:
0.0±3.1 mmHg at 25°C

[ 折射率 ]:
1.905

[ 储存条件 ]:
−20°C

腺苷2'(3')-单磷酸盐混合异构体MSDS

腺苷2'(3')-单磷酸盐混合异构体毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU7480300

CHEMICAL NAME :: 2'-Adenylic acid

CAS REGISTRY NUMBER :: 130-49-4

BEILSTEIN REFERENCE NO. :: 0058366

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H14-N5-O7-P

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 60,251,1954

腺苷2'(3')-单磷酸盐混合异构体安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AU7480300

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腺苷2'(3')-单磷酸盐混合异构体文献

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Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.

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