黑色素聚集激酶素(MCH)

黑色素聚集激酶素(MCH)用途

MCH (human, mouse, rat) 是一种有效的 MCH-R 的肽激动剂,与 MCH1R 和 MCH2R 结合的 IC50 值分别为 0.3nM 和 1.5 nM。MCH (human, mouse, rat) 对 CHO 细胞系中 MCH-2R 高度敏感,通过 FLIPR 监测细胞内钙动员,显示出功能性激活 MCH-1R 和 MCH-2R 的 EC50 值对分别为 3.9 nM 和 0.1 nM。

黑色素聚集激酶素(MCH)名称

[ CAS 号 ]:
128315-56-0

[ 中文名 ]:
黑色素聚集激酶素(MCH)

[ 英文名 ]:
MCH(human, mouse, rat)

[英文别名 ]:

MFCD00080193
Melanin Concentrating Hormone,human,mouse
Melanin concentrating hormone,human,mouse,rat

黑色素聚集激酶素(MCH)生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> MCHR1(GPR24)

研究领域 >> 神经疾病

[ 靶点 ]

Binding IC50: 0.3 nM (MCH1R) IC50: 1.5 nM (MCH1R)[1]

[参考文献]

[1]. A W Sailer, et al. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7564-9.

黑色素聚集激酶素(MCH)物理化学性质

[ 分子式 ]:
C₁₀₅H₁₆₀N₃₀O₂₆S₄

[ 分子量 ]:
2386.84000

[ 精确质量 ]:
2385.10000

[ PSA ]:
1018.94000

[ LogP ]:
6.54720

[ 外观性状 ]:
白色粉末

[ 储存条件 ]:
-20°C

黑色素聚集激酶素(MCH)安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
T+

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

黑色素聚集激酶素(MCH)文献

The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor.

Nat. Cell Biol. 12 , 267-271, (1999)

Gene-knockout studies of melanin-concentrating hormone (MCH) and its effect on feeding and energy balance have firmly established MCH as an orexigenic (appetite-stimulating) peptide hormone. Here we i...

Molecular characterization of the melanin-concentrating-hormone receptor.

Nature 400 , 265-269, (1999)

Orphan G-protein-coupled receptors (GPCRs) are cloned proteins with structural characteristics common to the GPCRs but that bind unidentified ligands. Orphan GPCRs have been used as targets to identif...

Investigation of the feeding effects of melanin concentrating hormone on food intake--action independent of galanin and the melanocortin receptors.

Brain Res. 846 , 164-170, (1999)

Melanin concentrating hormone (MCH) is recognised as a hypothalamic appetite stimulant. The mechanism of action of MCH is undetermined largely due to lack of identification of hypothalamic MCH recepto...

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