双氢链霉素

双氢链霉素用途

属抗生素类药，主要用于固紫染色阴性杆菌感染，也可用于结核杆菌感染。

双氢链霉素名称

[ CAS 号 ]:
128-46-1

[ 中文名 ]:
双氢霉素

[ 英文名 ]:
Dihydrostreptomycin

[中文别名 ]:

[英文别名 ]:

双氢链霉素物理化学性质

[ 密度 ]:
2.0±0.1 g/cm3

[ 沸点 ]:
879.5±75.0 °C at 760 mmHg

[ 熔点 ]:
210 - 212ºC

[ 分子式 ]:
C21H41N7O12

[ 分子量 ]:
583.590

[ 闪点 ]:
485.7±37.1 °C

[ 精确质量 ]:
583.281311

[ PSA ]:
334.59000

[ LogP ]:
-3.38

[ 外观性状 ]:
略米色固体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.762

双氢链霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WK2450000
CHEMICAL NAME :
Streptamine, O-beta-D-mannopyranosyl-(1-4)-2-deoxy-2-(methylamino) -alpha-L-glucopyranos yl- (1-2)-5-deoxy-O-3-C-(hydroxymethyl)-alpha-L-lyxofuran osyl-(1-4)-N,N'-diami dino-, D-
CAS REGISTRY NUMBER :
128-46-1
LAST UPDATED :
199603
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C21-H41-N7-O12
MOLECULAR WEIGHT :
583.69
WISWESSER LINE NOTATION :
T6OTJ CM1 DQ EQ F1Q BO- CT5OTJ DQ D1Q E1 BO- AL6TJ BQ CQ DMYZUM EQ FMYZUM

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
533 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
260 mg/kg
SEX/DURATION :
female 19-22 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
400 mg/kg
SEX/DURATION :
female 1-16 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
600 mg/kg
SEX/DURATION :
female 6-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
7500 mg/kg
SEX/DURATION :
female 5-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
12 gm/kg
SEX/DURATION :
female 1-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
REFERENCE :
NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta 700 019, India) V.1- 1958- Volume(issue)/page/year: 14,161,1971

双氢链霉素合成路线

详细合成路线

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