硫酸链霉素

硫酸链霉素用途

用于结核、布氏及非溶血性链球杆菌所致感染性心内膜炎、鼠疫与兔热病、流感杆菌和革兰阴性杆菌感染的治疗

硫酸链霉素作用

硫酸链霉素对多数革兰阳性菌和阴性菌都有抗菌作用，特别是对多种革兰阴性杆菌如大肠杆菌、沙门菌、巴氏杆菌、布氏杆菌、肺炎杆菌、痢疾杆菌、产气杆菌、鼻疽杆菌等有抗菌作用。本品是抗结核杆菌的首选药，对结核杆菌作用较强，在低浓度时有很强的抑菌作用，高浓度时有杀菌作用。因仅有10%能渗入体细胞内，故对细胞内的结核菌无效，只能杀灭细胞外的结核菌。对繁殖期细菌比静息期细菌有更强的杀菌作用。与青霉素不同的是，其杀菌速度与药物浓度呈正比，其抗菌作用在pH值7.8时最强，pH值降至6以下时则作用大大减弱。
农用硫酸链霉素属抗生素类杀菌剂，对多种作物的细菌性病害有防治作用，对一些真菌病害也有一定的防治作用。按我国农药毒性分级标准，链霉素属低毒杀菌剂。原药大鼠急性经口LD50>9 000mg/kg体重。可引起皮肤过敏反应。

硫酸链霉素名称

[ CAS 号 ]:
3810-74-0

[ 中文名 ]:
硫酸链霉素

[ 英文名 ]:
Steptomycin sulfate

[中文别名 ]:

[英文别名 ]:

MFCD00037023
Streptomycin sulfate salt
Streptomycin Sulfate
EINECS 223-286-0
Streptomycin Sulphate
Streptomycin (sulfate)

硫酸链霉素生物活性

[ 描述 ]:

Streptomycin sulfate 是一种氨基糖苷类抗生素,能够抑制蛋白质的合成。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[体外研究]

随着生长培养基中CV浓度的增加,菌株RB1显示出对链霉素的增强的易感性。随着生长培养基中CV浓度的增加,细胞色素aa3水平和链霉素敏感性均增加。细胞色素aa3是枯草芽孢杆菌积累链霉素所必需的[1]。链霉素影响tRNA选择。链霉素抗性突变通常映射到蛋白质S12,并且大多数这些变体在tRNA选择过程中表现出增加的区分[2]。

[参考文献]

[1]. McEnroe AS, et al. Correlation between cytochrome aa3 concentrations and streptomycin accumulation in Bacillus subtilis. Antimicrob Agents Chemother. 1984 Oct;26(4):507-12.

[2]. Sharma, D., et al., Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosome. J Mol Biol, 2007. 374(4): p. 1065-76.

[相关活性小分子]

硫酸链霉素物理化学性质

[ 沸点 ]:
948.2ºC at 760 mmHg

[ 分子式 ]:
C₂₁H₄₂N₇O₁₈S_1.5

[ 分子量 ]:
728.69

[ 闪点 ]:
527.3ºC

[ PSA ]:
911.80000

[ 外观性状 ]:
白色至灰白色粉末

[ 折射率 ]:
-85 ° (C=1, H2O)

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
>=0.01 G/100 ML AT 18 ºC

硫酸链霉素MSDS

详细MSDS(安全技术说明书)

硫酸链霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WK4990000

CAS REGISTRY NUMBER :: 3810-74-0

LAST UPDATED :: 199801

DATA ITEMS CITED :: 24

MOLECULAR FORMULA :: C42-H78-N14-O24.H6-O12-S3

MOLECULAR WEIGHT :: 1457.58

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Human - infant

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 430 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 430 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 403 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 548 gm/kg/2Y-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1095 gm/kg/2Y-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 11651 mg/kg/93D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Ear) - changes in vestibular functions

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 3 gm/kg/30D-I

TOXIC EFFECTS :: Behavioral - ataxia Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 4200 mg/kg/42D-I

TOXIC EFFECTS :: Behavioral - ataxia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 1350 mg/kg/27D-I

TOXIC EFFECTS :: Behavioral - ataxia Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 1700 mg/kg

SEX/DURATION :: female 26-39 week(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - eye/ear

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 37 gm/kg

SEX/DURATION :: multigenerations

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 1200 mg/kg

SEX/DURATION :: female 9-11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1 mg/plate

REFERENCE :: NTPTB* NTP Technical Bulletin. (National Toxicology Program, Landow Bldg. 3A-06, 7910 Woodmont Ave., Bethesda, MD 20205) Volume(issue)/page/year: JAN1982 *** REVIEWS *** TOXICOLOGY REVIEW PMMDAE Panminerva Medica. (Edizioni Minerva Medica, Casella Postale 491, Turin, Italy) V.1- 1959- Volume(issue)/page/year: 16,9,1974 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83938 No. of Facilities: 104 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 819 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83938 No. of Facilities: 296 (estimated) No. of Industries: 3 No. of Occupations: 8 No. of Employees: 4472 (estimated) No. of Female Employees: 2183 (estimated)

硫酸链霉素安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H361

[ 警示性声明 ]:
P281

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
2811.0

[ WGK德国 ]:
3

[ RTECS号 ]:
WK4990000

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2941200000

硫酸链霉素海关

[ 海关编码 ]: 2941200000

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