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1,2-二苯肼

1,2-二苯肼用途

【用途一】
用作有机合成原料，也用于制解热止痛类药物保太松
【用途二】
医药工业用于生产解热镇痛药保泰松；染料工业用于制造联苯胺染料等。

1,2-二苯肼名称

[ CAS 号 ]:
122-66-7

[ 中文名 ]:
1,2-二苯肼

[ 英文名 ]:
1,2-Diphenylhydrazine

[中文别名 ]:

[英文别名 ]:

1,2-Diphenylhydrazine (9CI)
N,N'-Diphenylhydrazine
1,2-diphenyldiazane
Hydrazobenzen [Czech]
Hydrazobenzen
Hydrazine,1,2-diphenyl
N,N'-Bianiline
Benzene,hydrazodi
hydrazobenzene
Hydrazine, 1,2-diphenyl-

1,2-二苯肼物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
229.3±13.0 °C at 760 mmHg

[ 熔点 ]:
123-126 °C(lit.)

[ 分子式 ]:
C₁₂H₁₂N₂

[ 分子量 ]:
184.237

[ 闪点 ]:
87.7±14.9 °C

[ 精确质量 ]:
184.100052

[ PSA ]:
24.06000

[ LogP ]:
2.94

[ 外观性状 ]:
橙色-黄色至橙色粉末

[ 蒸汽压 ]:
0.1±0.5 mmHg at 25°C

[ 折射率 ]:
1.700

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品添加剂、酸类分开存放

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, strong acids.

[ 水溶解性 ]:
水溶性：实际上不溶；微溶：苯

1,2-二苯肼MSDS

1,2-二苯肼毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MW2625000

CHEMICAL NAME :: Hydrazobenzene

CAS REGISTRY NUMBER :: 122-66-7

BEILSTEIN REFERENCE NO. :: 0639793

LAST UPDATED :: 199710

DATA ITEMS CITED :: 21

MOLECULAR FORMULA :: C12-H12-N2

MOLECULAR WEIGHT :: 184.26

WISWESSER LINE NOTATION :: RMMR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2620 mg/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5200 mg/kg/52W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 26 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5280 mg/kg/26W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8400 mg/kg/38W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9820 mg/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 36 gm/kg/53W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Reproductive - Tumorigenic effects - uterine tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16 gm/kg/1Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6 gm/kg/27W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Reproductive - Tumorigenic effects - uterine tumors

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 5 mg/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5870 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 977 (estimated) No. of Female Employees: 154 (estimated)

1,2-二苯肼安全信息

[ 符号 ]:

GHS07, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H350-H410

[ 警示性声明 ]:
P201-P273-P308 + P313-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R45;R22;R50/53

[ 安全声明 (欧洲) ]:
S53-S45-S60-S61

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
MW2625000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2928000090

1,2-二苯肼合成路线

1,2-二苯肼上下游产品

1,2-二苯肼上游产品

1,2-二苯肼下游产品

1,2-二苯肼制备

由硝基苯经还原得到的二苯肼有两种方法。1.用锌粉还原；2.用葡萄糖和硅粉还原。

1,2-二苯肼海关

[ 海关编码 ]: 2928000090

[ 中文概述 ]:
2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

1,2-二苯肼文献

Development of QSAR models for predicting hepatocarcinogenic toxicity of chemicals.

Eur. J. Med. Chem. 44 , 3658-64, (2009)

A dataset comprising 55 chemicals with hepatocarcinogenic potency indices was collected from the Carcinogenic Potency Database with the aim of developing QSAR models enabling prediction of the above u...

In situ infrared monitoring of the solid/liquid catalyst interface during the three-phase hydrogenation of nitrobenzene over nanosized Au on TiO2.

Phys. Chem. Chem. Phys. 13(27) , 12463-71, (2011)

The three-phase hydrogenation of nitrobenzene catalysed by nanosized gold over titania was investigated in a slurry. Simultaneous in situ ATR-FTIR monitoring of the liquid phase and at the solid/liqui...

The effect of replacing carbon by nitrogen in reductions with SmI2: reduction of azobenzene.

J. Org. Chem. 76(22) , 9438-43, (2011)

The reduction of azobenzene by SmI(2) in THF to give hydrazobenzene was investigated. The kinetics are first order in the substrate and first order in SmI(2). The kinetic order in MeOH is ca. 0.56, an...

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