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6-氰基-7-硝基喹喔啉-2,3-二酮

6-氰基-7-硝基喹喔啉-2,3-二酮用途

CNQX (FG9065) 是高效的 AMPA/kainate 受体拮抗剂。

6-氰基-7-硝基喹喔啉-2,3-二酮名称

[ CAS 号 ]:
115066-14-3

[ 中文名 ]:
6-氰基-7-硝基喹喔啉-2,3-二酮

[ 英文名 ]:
CNQX

[中文别名 ]:

[英文别名 ]:

CNQX disodium salt hydrate
CNQX 2NA
6-Nitro-7-cyanoquinoxaline-2,3-dione
MFCD00069232
6-Cyano-7-nitroquinoxaline-2,3-dione FG-9065
2,3-Dihydroxy-7-nitroquinoxaline-6-carbonitrile
CNQX DISODIUM
CNOX
CNQX DISODIUM SALT
CNQX

6-氰基-7-硝基喹喔啉-2,3-二酮生物活性

[ 描述 ]:

CNQX (FG9065) 是高效的 AMPA/kainate 受体拮抗剂。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> iGluR

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

[体外研究]

在沐浴在不含Mg2 +的培养基中的大鼠海马切片中,10μMCNXX可逆地阻断对α-氨基-3-羟基-5-甲基-4-异恶唑-丙酸(AMPA),quisqualate和红藻氨酸但不是NMDA的反应[1]。用6-氰基-7-硝基喹喔啉-2,3-二酮(CNQX,2-5μM)灌注海马切片可逆地阻断Schaffer侧枝和苔藓纤维兴奋性突触后电位(EPSP),同时保留快速和慢速GABA介导的抑制[2]。 CNQX(1-5μM)产生从腰椎节段记录的DR-VRR单突触组分振幅的选择性和剂量依赖性降低[3]。 CNQX介导的去极化由AMPAR介导,但不是TRN神经元中的红藻氨酸受体[4]。

[体内研究]

在保留测试前10分钟将CNQX(0.5或1.25μg)双侧输注到杏仁核或背侧海马中,在训练后24小时部分阻断了大鼠中降压抑制避免的表达。 CNQX以0.5μg的剂量引起完全阻断[5]。

[细胞实验]

CNQX通过使用电动注射泵在60秒内将注射液注入腔室的输入管线来施加。在神经元亚群中，CNQX应用浴5分钟。控制注射生理盐水或载体（DMSO）不会改变电压记录期间的膜电位/输入电阻[4]。

[参考文献]

[1]. Blake JF, et al. CNQX blocks acidic amino acid induced depolarizations and synaptic components mediated by non-NMDA receptors in rathippocampal slices. Neurosci Lett. 1988 Jun 29;89(2):182-6.

[2]. Neuman RS, et al. Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione(CNQX) in the hippocampus in vitro. Neurosci Lett. 1988 Sep 23;92(1):64-8.

[3]. Alford S, et al. CNQX and DNQX block non-NMDA synaptic transmission but not NMDA-evoked locomotion in lamprey spinal cord. Brain Res. 1990 Jan 8;506(2):297-302.

[4]. Lee SH, et al. Selective excitatory actions of DNQX and CNQX in rat thalamic neurons. J Neurophysiol. 2010 Apr;103(4):1728-34.

[5]. Kim M, et al. Infusion of the non-NMDA receptor antagonist CNQX into the amygdala blocks the expression of fear-potentiated startle. Behav Neural Biol. 1993 Jan;59(1):5-8.

[相关活性小分子]

6-氰基-7-硝基喹喔啉-2,3-二酮物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
659.3ºC at 760 mmHg

[ 熔点 ]:
300 °C

[ 分子式 ]:
C₉H₄N₄O₄

[ 分子量 ]:
232.152

[ 闪点 ]:
352.6ºC

[ 精确质量 ]:
232.023254

[ PSA ]:
135.33000

[ LogP ]:
0.64

[ 外观性状 ]:
淡黄色固体

[ 蒸汽压 ]:
0.001mmHg at 25°C

[ 折射率 ]:
1.699

[ 储存条件 ]:
Desiccate at RT

[ 稳定性 ]:
Store Tightly Sealed at RT

[ 水溶解性 ]:
H2O: 10 mg/mL

6-氰基-7-硝基喹喔啉-2,3-二酮MSDS

详细MSDS(安全技术说明书)

6-氰基-7-硝基喹喔啉-2,3-二酮安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

6-氰基-7-硝基喹喔啉-2,3-二酮文献

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