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4-羟基二苯甲酮

4-羟基二苯甲酮用途

【用途一】
用作医药中间体
【用途二】
用于有机合成，是抗不育症药物放氯米芬的中间体。
【用途三】
本品用于药物合成和抗紫外线。

4-羟基二苯甲酮名称

[ CAS 号 ]:
1137-42-4

[ 中文名 ]:
4-羟基-二苯甲酮

[ 英文名 ]:
4-Hydroxybenzophenone

[中文别名 ]:

[英文别名 ]:

1-benzoyl-4-hydroxy-benzene
P-HYDROXYBENZOPHENONE
POB
4-Hydroxybenzophenone
P-BENZOYLPHENOL
(4-Hydroxyphenyl)(phenyl)methanone
4-Hydroxybenzophene
4-BENZOYLPHENOL
Methanone, (4-hydroxyphenyl)phenyl-
PARA-BENZOYLPHENOL

4-羟基二苯甲酮物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
367.3±25.0 °C at 760 mmHg

[ 熔点 ]:
132-135 °C(lit.)

[ 分子式 ]:
C₁₃H₁₀O₂

[ 分子量 ]:
198.217

[ 闪点 ]:
156.7±15.8 °C

[ 精确质量 ]:
198.068085

[ PSA ]:
37.30000

[ LogP ]:
2.87

[ 外观性状 ]:
白色至灰色至棕色粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.615

[ 储存条件 ]:
Refrigerator

4-羟基二苯甲酮MSDS

4-羟基二苯甲酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PC4959775

CHEMICAL NAME :: Methanone, (4-hydroxyphenyl)phenyl-

CAS REGISTRY NUMBER :: 1137-42-4

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C13-H10-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12086 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (2),25,1994

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3724 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (2),25,1994

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1154 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (2),25,1994

4-羟基二苯甲酮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
PC4959775

[ 海关编码 ]:
2914501900

4-羟基二苯甲酮合成路线

4-羟基二苯甲酮上下游产品

4-羟基二苯甲酮上游产品

4-羟基二苯甲酮下游产品

4-羟基二苯甲酮制备

由苯甲酸苯酯加热重排而得。将苯甲酸苯酯加热至70℃熔融，搅拌下迅速投入无水三氯化铝，反应逸出氯化氢，并自行升温，在130℃反应15min。冷却，加入稀盐酸。过滤，水洗至中性。滤饼用苯重结晶，得4-羟基二苯酮，收率62%。

4-羟基二苯甲酮海关

[ 海关编码 ]: 2914501900

[ 中文概述 ]:
2914501900 其他酮酚。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

4-羟基二苯甲酮文献

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Talanta 134 , 657-64, (2015)

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