紫外线吸收剂UV-0

紫外线吸收剂UV-0用途

DHBP, also known as Benzoresorcinol, is an activator of WalKR TCS. It works via targeting erWalK and selectively promoting the lysostaphin-induced lysis activity of the Newman wild-type strain.

紫外线吸收剂UV-0名称

[ CAS 号 ]:
131-56-6

[ 中文名 ]:
2,4-二羟二苯甲酮

[ 英文名 ]:
2,4-Dihydroxybenzophenone

[中文别名 ]:

[英文别名 ]:

SYNSORB
UV-0
hhb
Seesorb 100
2,4-DHBP
2,4-dihydroxy-benzophenone
Uf 1
4-Benzoylresorcinol
EINECS 205-029-4
BP-1

紫外线吸收剂UV-0物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
409.0±14.0 °C at 760 mmHg

[ 熔点 ]:
144.5-147 °C(lit.)

[ 分子式 ]:
C₁₃H₁₀O₃

[ 分子量 ]:
214.217

[ 闪点 ]:
215.3±16.6 °C

[ 精确质量 ]:
214.062988

[ PSA ]:
57.53000

[ LogP ]:
3.17

[ 外观性状 ]:
淡黄色,结晶固体

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.648

[ 储存条件 ]:
-20°C

[ 水溶解性 ]:
insoluble

紫外线吸收剂UV-0MSDS

紫外线吸收剂UV-0毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ0700000

CHEMICAL NAME :: Benzophenone, 2,4-dihydroxy-

CAS REGISTRY NUMBER :: 131-56-6

BEILSTEIN REFERENCE NO. :: 1311566

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C13-H10-O3

MOLECULAR WEIGHT :: 214.23

WISWESSER LINE NOTATION :: QR CQ DVR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,652,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8600 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea

REFERENCE :: RPZHAW Roczniki Panstwowego Zakladu Higieny. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950- Volume(issue)/page/year: 19,179,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 85 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 22,221,1964 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 54600 mg/kg/91D-I

TOXIC EFFECTS :: Liver - changes in liver weight Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count

REFERENCE :: RPZHAW Roczniki Panstwowego Zakladu Higieny. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950- Volume(issue)/page/year: 19,179,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5161 No. of Facilities: 1090 (estimated) No. of Industries: 8 No. of Occupations: 20 No. of Employees: 6623 (estimated) No. of Female Employees: 981 (estimated)

紫外线吸收剂UV-0安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
DJ0700000

[ 包装等级 ]:
II; III

[ 危险类别 ]:
4.1

[ 海关编码 ]:
29145000

紫外线吸收剂UV-0合成路线

紫外线吸收剂UV-0上下游产品

紫外线吸收剂UV-0上游产品

紫外线吸收剂UV-0下游产品

紫外线吸收剂UV-0制备

有4种主要生产方法： 1以间苯二酚和苯甲酰氯为原料将苯甲酰氯和间苯二酚加入反应釜，再加入溶剂氯苯和催化剂三氯化铝进行反应，脱除氯化氢，生成2,4-二羟基二苯甲酮。反应完成后，反应产物经蒸馏脱除溶剂和低沸物，再经脱色、干燥而制得成品. 此法产品色泽好，几乎是白色结晶，但原料成本高，反应收率只有50%～60%，且产生大量的废催化剂。 2以间苯二酚和三氯甲苯为原料在反应釜中投入间苯二酚及适量水，搅拌溶解。再加入三氯甲苯和适量酒精，搅拌下使物料全部混溶。控制40℃进行反应，生成2,4-二羟基二苯甲酮以固体析出。反应完成后，反应物经过滤，滤饼用稀碳酸氢钠溶液洗涤，再进行干燥，即得成品。此法收率可达95%，原料易得，产品成本低。但产品色泽较深，不易脱色提纯。

3以苯甲酸和间苯二酚为原料将苯甲酸和间苯二酚及催化剂氧化锌投入反应釜，搅拌下加热升温进行反应。在反应中加入三氯化磷或磷酸来提高脱水反应速度。

此法收率可达90%以上。但原料苯甲酸易升华，粘附于反应器壁上，反应时间较长，熔融物排放操作困难。

4将苯酐与间苯二酚加入反应釜，再加入溶剂喹啉和催化剂铜粉进行缩合反应，制得2-(2’,4’-二羟基苯甲酰)苯甲酸，再经脱羧反应而得2,4-二羟基二苯甲酮。

此法收率低。

紫外线吸收剂UV-0海关

[ 海关编码 ]: 29145000

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