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VU0357017盐酸盐

VU0357017盐酸盐用途

VU0357017盐酸盐是一种高度选择性M1受体激动剂, 作用于变构位点, 激活受体(EC50=477 ± 172 nM, pEC50=6.37 ± 0.15)。

VU0357017盐酸盐名称

[ CAS 号 ]:
1135242-13-5

[ 中文名 ]:
VU0357017盐酸盐

[ 英文名 ]:
VU0357017

[英文别名 ]:

VU 0357017 Hydrochloride
VU0357017 monohydrochloride
ML071 hydrochloride
VU0357017
VU0357017 (hydrochloride)

VU0357017盐酸盐生物活性

[ 描述 ]:

VU0357017盐酸盐是一种高度选择性M1受体激动剂, 作用于变构位点, 激活受体(EC50=477 ± 172 nM, pEC50=6.37 ± 0.15)。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR

信号通路 >> 神经信号通路 >> mAChR

研究领域 >> 神经疾病

[参考文献]

[1]. Digby GJ, et al. Chemical modification of the M(1) agonist VU0364572 reveals molecular switches in pharmacology and a bitopic binding mode. ACS Chem Neurosci. 2012 Dec 19;3(12):1025-36.

[2]. Lebois EP, et al. Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system. ACS Chem Neurosci. 2010;1(2):104-121.

[3]. Digby GJ, et al. Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models. J Neurosci. 2012 Jun 20;32(25):8532-44.

[4]. Sheffler DJ, et al. Further exploration of M? allosteric agonists: subtle structural changes abolish M? allosteric agonism and result in pan-mAChR orthosteric antagonism. Bioorg Med Chem Lett. 2013 Jan 1;23(1):223-7.

[相关活性小分子]

VU0357017盐酸盐物理化学性质

[ 分子式 ]:
C₁₈H₂₈ClN₃O₃

[ 分子量 ]:
369.88600

[ 精确质量 ]:
369.18200

[ PSA ]:
74.16000

[ LogP ]:
3.64090

[ 储存条件 ]:
2-8℃

VU0357017盐酸盐MSDS

详细MSDS(安全技术说明书)

VU0357017盐酸盐安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

VU0357017盐酸盐文献

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