Coformycin

Coformycin用途

Coformycin 是一种核苷类抗生素,是腺苷脱氨酶 (adenosine deaminase , ADA) 的抑制剂。Coformycin 具有抗肿瘤和抗菌活性。

Coformycin名称

[ CAS 号 ]:
11033-22-0

[ 英文名 ]:
Imidazo[4,5-d][1,3]diazepin-8-ol,3,4,7,8-tetrahydro-3-b-D-ribofuranosyl-, (8R)-

[英文别名 ]:

Coformycin

Coformycin生物活性

[ 描述 ]:

Coformycin 是一种核苷类抗生素,是腺苷脱氨酶 (adenosine deaminase , ADA) 的抑制剂。Coformycin 具有抗肿瘤和抗菌活性。

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> 代谢酶/蛋白酶 >> 腺苷脱氨酶

信号通路 >> 抗感染 >> 细菌

[体内研究]

咖啡霉素(0.2mg/kg,每日ip)抑制脑、心、肾、肝等多种组织的腺苷脱氨酶活性[2]。动物模型：瑞士韦氏小鼠[2]。用量：0.2mg/kg。管理：IP每日。结果：对不同组织腺苷脱氨酶活性均有抑制作用。

[参考文献]

[1]. Coformycin.

[2]. Lukey T, et al. S-adenosylhomocysteine hydrolase activity, deoxyadenosine triphosphate accumulation, and competence of thymocyte and spleen leucocyte response to mitogens in coformycin-treated mice. Biochem Pharmacol. 1983 Apr 15;32(8):1399-406.

Coformycin物理化学性质

[ 密度 ]:
1.96g/cm3

[ 沸点 ]:
692.7ºC at 760mmHg

[ 分子式 ]:
C₁₁H₁₆N₄O₅

[ 分子量 ]:
284.26900

[ 闪点 ]:
372.7ºC

[ 精确质量 ]:
284.11200

[ PSA ]:
132.36000

[ 蒸汽压 ]:
3.84E-20mmHg at 25°C

[ 折射率 ]:
1.828

Coformycin毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI2931500

CHEMICAL NAME :: Imidazo(4,5-d)(1,3)diazepin-8-ol, 3,4,7,8-tetrahydro-3-beta-D-ribofuranosyl-, (R)-

CAS REGISTRY NUMBER :: 11033-22-0

LAST UPDATED :: 198311

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H16-N4-O5

MOLECULAR WEIGHT :: 284.31

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,330,1981