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刀豆凝集素A

刀豆凝集素A用途

刀豆蛋白A是一种钙/锰依赖性和甘露糖/葡萄糖结合的植物凝集素,可以在菜豆中找到。伴刀豆球蛋白A可诱导程序性细胞死亡[1]。

刀豆凝集素A名称

[ CAS 号 ]:
11028-71-0

[ 中文名 ]:
伴刀豆球蛋白A

[ 英文名 ]:
Concanavalin A

[中文别名 ]:

刀豆蛋白 A

[英文别名 ]:

EINECS 234-258-2
MFCD00071069

刀豆凝集素A生物活性

[ 描述 ]:

刀豆蛋白A是一种钙/锰依赖性和甘露糖/葡萄糖结合的植物凝集素,可以在菜豆中找到。伴刀豆球蛋白A可诱导程序性细胞死亡[1]。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

研究领域 >> 感染

研究领域 >> 炎症/免疫

[参考文献]

[1]. Li W, et, al. Concanavalin A: a potential anti-neoplastic agent targeting apoptosis, autophagy and anti-angiogenesis for cancer therapeutics. Biochem Biophys Res Commun. 2011 Oct 22;414(2):282-6.

[2]. Cantelli A, et, al. Concanavalin A-Rose Bengal bioconjugate for targeted Gram-negative antimicrobial photodynamic therapy. J Photochem Photobiol B. 2020 Mar 13;206:111852.

刀豆凝集素A物理化学性质

[ 分子式 ]:
C₁₅H₂₄

[ 分子量 ]:
304.35

[ 闪点 ]:
39 °C

[ 外观性状 ]:
powder

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
PBS: 5 mg/mL, slightly hazy | Slightly soluble in water and phosfate buffered saline.

刀豆凝集素A安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H317-H334-H361

[ 警示性声明 ]:
P261-P280-P284-P304 + P340-P342 + P311

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R42/43

[ 安全声明 (欧洲) ]:
S36;S24/25

[ 危险品运输编码 ]:
UN 1170 3/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
GK6890000

[ 海关编码 ]:
35040090

刀豆凝集素A文献

The second virial coefficient as a predictor of protein aggregation propensity: A self-interaction chromatography study.

Eur. J. Pharm. Biopharm. 96 , 282-90, (2015)

The second osmotic virial coefficients (b2) of four proteins - lysozyme, recombinant human lactoferrin, concanavalin A and catalase were measured by self-interaction chromatography (SIC) in solutions ...

Osmolyte effects on the self-association of concanavalin A: testing theoretical models.

Biochemistry 52(51) , 9367-74, (2013)

The formation and stability of protein-protein interfaces are of obvious biological importance. While a large body of literature exists describing the effect of osmolytes on protein folding, very few ...

Cellular interaction of nontypeable Haemophilus influenzae triggers cytotoxicity of infected type II alveolar cells via apoptosis.

Pathog. Dis. 73(2) , 1-12, (2015)

Nontypeable Haemophilus influenzae (NTHi) is an important cause of lower respiratory tract infections, resulting in exacerbations of chronic obstructive pulmonary disease (COPD). Despite its pathogeni...

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