<生产厂家价格>

三氟丙嗪盐酸盐

三氟丙嗪盐酸盐用途

Triflupromazine盐酸盐是吩噻嗪类的抗精神病药物，是多巴胺受体 D1 / D2拮抗剂，用于治疗严重的心理障碍。

三氟丙嗪盐酸盐名称

[ CAS 号 ]:
1098-60-8

[ 中文名 ]:
三氟丙嗪盐酸盐

[ 英文名 ]:
Triflupromazine hydrochloride

[中文别名 ]:

盐酸三氟丙嗪

[英文别名 ]:

Triflupromazine HCl
Fluorofen
Nivoman
Trifluopromazine hydrochloride
flupromazine hydrochloride
Fluopromazinhydrochlorid
Vesprin hydrochloride
Neoprin
Flumazin
MFCD00058103

三氟丙嗪盐酸盐生物活性

[ 描述 ]:

Triflupromazine盐酸盐是吩噻嗪类的抗精神病药物,是多巴胺受体 D1/D2拮抗剂,用于治疗严重的心理障碍。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

信号通路 >> 神经信号通路 >> 多巴胺受体

研究领域 >> 神经疾病

[相关活性小分子]

三氟丙嗪盐酸盐物理化学性质

[ 沸点 ]:
427.6ºC at 760 mmHg

[ 熔点 ]:
174.0 to 179.0 °C

[ 分子式 ]:
C₁₈H₂₀ClF₃N₂S

[ 分子量 ]:
388.878

[ 闪点 ]:
212.4ºC

[ 精确质量 ]:
388.098785

[ PSA ]:
31.78000

[ LogP ]:
6.12680

[ 外观性状 ]:
晶体

[ 蒸汽压 ]:
1.62E-07mmHg at 25°C

[ 储存条件 ]:
室温

[ 水溶解性 ]:
水溶性：可溶；可溶于：乙醇,丙酮

三氟丙嗪盐酸盐MSDS

详细MSDS(安全技术说明书)

三氟丙嗪盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SO8925000

CHEMICAL NAME :: Phenothiazine, 10-(3-(dimethylamino)propyl)-2-(trifluoromethyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 1098-60-8

LAST UPDATED :: 199012

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C18-H19-F3-N2-S.Cl-H

MOLECULAR WEIGHT :: 388.91

WISWESSER LINE NOTATION :: T C666 BN ISJ B3N1&1 EXFFF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 94 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 254 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 102 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 34 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory obstruction Blood - hemorrhage

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Mammal - species unspecified Kidney

DOSE/DURATION :: 10 mg/L

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 8,617,1970

三氟丙嗪盐酸盐安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H312 + H332

[ 警示性声明 ]:
Missing Phrase - N15.00950417-P261-P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
36

[ 危险品运输编码 ]:
UN 2811 6

[ WGK德国 ]:
3

[ RTECS号 ]:
SO8925000

[ 包装等级 ]:
III