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马加宁I

马加宁I用途

Magainin 1是在非洲爪蟾皮肤中发现的抗微生物多肽。

马加宁I名称

[ CAS 号 ]:
108433-99-4

[ 中文名 ]:
马加宁I

[ 英文名 ]:
Magainin 1

[英文别名 ]:

MAGAININ 1 (FROG,XENOPUS LAEVIS)
GIGKFLHSAGKFGKAFVGEIMKS
MAGAININ 1

马加宁I生物活性

[ 描述 ]:

Magainin 1是在非洲爪蟾皮肤中发现的抗微生物多肽。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

信号通路 >> 抗感染 >> 真菌

多肽产品

研究领域 >> 感染

天然产物 >> 其他

[体外研究]

Magainin 1通过透化细胞膜杀死细菌而不显示对哺乳动物细胞的显着毒性。肽的主要目标被认为是膜的脂质基质[1]。 Magainin 1和2具有相似的氨基酸序列。 Magainin 2具有比magainin 1更高的抗菌活性[2]。 Magainin 1通过静电相互作用与酸性脂质相互作用,然后通过疏水相互作用形成两亲性螺旋,从而引发渗漏。 Magainin 1特异性地诱导钙黄绿素从带负电荷的囊泡中泄漏。根据Langmuir等温线,该肽与牛脑磷脂酰丝氨酸超声囊泡结合,结合常数为3.8×105 M-1,每个脂质分子的结合位点数为0.10 [3]。 Magainin 2显示抗大量革兰氏阴性和革兰氏阳性细菌的抗生素活性。在magainin 1的测定中可以看到类似的活性谱[4]。

[参考文献]

[1]. Matsuzaki K, et al. Magainins as paradigm for the mode of action of pore forming polypeptides. Biochim Biophys Acta. 1998 Nov 10;1376(3):391-400.

[2]. Watanabe H, et al. Channel Current Analysis for Pore-forming Properties of an Antimicrobial Peptide, Magainin 1, Using the Droplet Contact Method. Anal Sci. 2016;32(1):57-60.

[3]. Matsuzaki K, et al. Magainin 1-induced leakage of entrapped calcein out of negatively-charged lipid vesicles. Biochim Biophys Acta. 1989 May 19;981(1):130-4.

[4]. Zasloff M, et al. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-53.

[相关活性小分子]

马加宁I物理化学性质

[ 分子式 ]:
C₁₁₂H₁₇₇N₂₉O₂₈S

[ 分子量 ]:
2409.85000

[ 精确质量 ]:
2408.30000

[ PSA ]:
939.34000

[ LogP ]:
4.96870

[ 储存条件 ]:
-20°C

马加宁I安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
T+

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

马加宁I文献

Targeting methicillin-resistant Staphylococcus aureus with short salt-resistant synthetic peptides.

Antimicrob. Agents Chemother. 58(7) , 4113-22, (2014)

The seriousness of microbial resistance combined with the lack of new antimicrobials has increased interest in the development of antimicrobial peptides (AMPs) as novel therapeutics. In this study, we...

In vitro efficacy of a synthetic all-d antimicrobial peptide against clinically isolated drug-resistant strains.

Int. J. Antimicrob. Agents 35(2) , 208-9, (2010)

NMR structural studies of membrane proteins.

Curr. Opin. Struct. Biol. 8(5) , 640-8, (1998)

The three-dimensional structures of membrane proteins are essential for understanding their functions, interactions and architectures. Their requirement for lipids has hampered structure determination...

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