环己胺_MSDS_用途_密度_环己胺CAS号【108-91-8】

【用途一】
用于制造活性染料、柔软剂VS和医药克脑迷噻替泒、亚胺醌等，也可用于医药、农药上。
【用途二】
用于有机合成、塑料合成，也用作防腐剂和酸性气体吸收剂
【用途三】
用作橡胶硫化促进剂，也用作合成纤维、染料、气相缓蚀剂的原料
【用途四】
环己胺是除草剂环嗪酮的中间体，也是橡胶促进剂、石油添加剂、阻蚀剂的中间体。
【用途五】
本品用以制备环己醇、环己酮、己内酰胺、醋酸纤维和尼龙6等。环己胺本身为溶剂，可在树脂、涂料、脂肪、石蜡油类中应用。也可用于制取脱硫剂、橡胶抗氧剂、硫化促进剂、塑料及纺织品化学助剂、锅炉给水处理剂、金属缓蚀剂、乳化剂、防腐剂、抗静电剂、胶乳凝固剂、石油添加剂、杀菌剂、杀虫剂及染料中间体。环己胺的磺酸盐，作为人工甘味料，用于食品、饮料和医药。
【用途六】
酸性气体吸收剂，有机合成。

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
134.5±0.0 °C at 760 mmHg

[ 熔点 ]:
-17 °C

[ 分子式 ]:
C₆H₁₃N

[ 分子量 ]:
99.174

[ 闪点 ]:
32.2±0.0 °C

[ 精确质量 ]:
99.104797

[ PSA ]:
26.02000

[ LogP ]:
1.39

[ 外观性状 ]:
透明至黄色液体

[ 蒸汽密度 ]:
3.42 (vs air)

[ 蒸汽压 ]:
8.1±0.2 mmHg at 25°C

[ 折射率 ]:
1.460

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 水溶解性 ]:
MISCIBLE

[ 凝固点 ]:
-17.7℃

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GX0700000

CHEMICAL NAME :: Cyclohexylamine

CAS REGISTRY NUMBER :: 108-91-8

BEILSTEIN REFERENCE NO. :: 0471175

LAST UPDATED :: 199806

DATA ITEMS CITED :: 81

MOLECULAR FORMULA :: C6-H13-N

MOLECULAR WEIGHT :: 99.20

WISWESSER LINE NOTATION :: L6TJ AZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Lungs, Thorax, or Respiration - pulmonary emboli Gastrointestinal - other changes

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7500 mg/m3

TOXIC EFFECTS :: Behavioral - excitement Behavioral - muscle contraction or spasticity

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 224 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1070 mg/m3

TOXIC EFFECTS :: Behavioral - excitement Behavioral - muscle contraction or spasticity

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 129 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 770 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 150 ppm/7H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 320 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1200 ppm/7H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Vascular - shock Liver - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 35700 mg/kg/1Y-C

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - other changes

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 700 mg/m3/2H/9W-I

TOXIC EFFECTS :: Cardiac - changes in heart weight Kidney, Ureter, Bladder - changes in bladder weight Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/m3/4H/22W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in cell count (unspecified) Nutritional and Gross Metabolic - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5600 mg/kg

SEX/DURATION :: male 4 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 300 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 100 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 5 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 600 mg/kg

SEX/DURATION :: female 6-11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 120 mg/kg

SEX/DURATION :: female 6-11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 61 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 77 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 200 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 250 mg/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 14 gm/kg

SEX/DURATION :: male 8 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 15750 mg/kg

SEX/DURATION :: male 9 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Dominant lethal test

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Mammal - species unspecified Kidney

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 8,617,1970 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 41 mg/m3 (10 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,178,1987 IARC Cancer Review:Animal NO EVIDENCE IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 22,55,1980 IARC Cancer Review:Human Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 22,55,1980 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,178,1987 TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 39,1,1976 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 ppm (40 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 10 ppm (40 mg/m3) JAN 1993 OEL-BELGIUM:TWA 10 ppm (41 mg/m3) JAN 1993 OEL-DENMARK:TWA 10 ppm (40 mg/m3);Skin JAN 1993 OEL-FINLAND:STEL 10 ppm (40 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 10 ppm (40 mg/m3) JAN 1993 OEL-GERMANY:TWA 10 ppm (40 mg/m3) JAN 1993 OEL-HUNGARY:TWA 1 mg/m3;STEL 2 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 10 ppm (40 mg/m3);Skin JAN 1993 OEL-RUSSIA:STEL 1 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 10 ppm (40 mg/m3);STEL 20 ppm;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 10 ppm (40 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CYCLOHEXYLAMINE-air:10H TWA 10 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84526 No. of Facilities: 3468 (estimated) No. of Industries: 63 No. of Occupations: 25 No. of Employees: 9450 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84526 No. of Facilities: 4729 (estimated) No. of Industries: 83 No. of Occupations: 47 No. of Employees: 64346 (estimated) No. of Female Employees: 2914 (estimated)

[ 符号 ]:

GHS02, GHS05, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H301 + H311-H314-H361f

[ 警示性声明 ]:
Missing Phrase - N15.00950417-P210-P280-P303 + P361 + P353-P305 + P351 + P338-P370 + P378

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R10;R21/22;R34

[ 安全声明 (欧洲) ]:
S36/37/39-S45-S1/2

[ 危险品运输编码 ]:
UN 2357 8/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
GX0700000

[ 包装等级 ]:
II

[ 危险类别 ]:
8

[ 海关编码 ]:
2921300090

详细合成路线

环己胺上游产品

环己胺下游产品

1.由苯胺催化加氢而得，可分为常压法和加压法。此外，通过环己烷或环己醇的催化氨解，硝基环己烷还原，以及氢存在下的环己酮催化氨解等方法均可制得环己胺。

精制方法：常含有苯胺和水等杂质。精制时首先将环己胺转变为盐酸盐，用水重结晶，精制后在碱性溶液中用乙醚萃取，固体氢氧化钾干燥，在氮气流中蒸馏。在4.65KPa的压力下精馏，可将苯胺除去。

2.以镍或钴为催化剂，在高温、高压下由苯胺进行催化还原得到。也可由苯酚催化还原得到环己醇，氧化为环己酮，再与氨进行氨基化而得到环己胺。

[ 海关编码 ]: 2921300090

[ 中文概述 ]:
2921300090 其他环（烷，烯，萜烯）单胺或多胺（包括其衍生物及它们的盐）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥78.0/500ml

联系人：刘佳

产品详情：环己胺

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥需询单/1mg ￥需询单/1g ￥需询单/1g ￥需询单/1g

联系人：阿拉丁李高志

产品详情：环己胺

公司名：济南创世化工有限公司

区域：济南市天桥区

价格：
￥需询单/175kg

联系人：严玲玲

产品详情：环己胺

公司名：山东金悦源新材料有限公司

区域：济南市天桥区

价格：
￥10000.0/1ton

联系人：王思兵

产品详情：环己胺

公司名：济南世纪通达化工有限公司

区域：济南市天桥区

价格：
￥14500.0/1ton ￥28000.0/2ton

联系人：王经理

产品详情：环己胺

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环己胺名称

环己胺物理化学性质

环己胺MSDS

详细MSDS(安全技术说明书)

环己胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

环己胺安全信息

环己胺合成路线

详细合成路线

环己胺上下游产品

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