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N,N-二甲基异丙醇胺

N,N-二甲基异丙醇胺用途

【用途一】
用于制药工业，也用作丙烯腈聚合物的稳定剂
【用途二】
用作药物异丙嗪、美散痛的中间体。也用作丙烯腈聚合物的稳定剂。1-二甲氨基-2-丙醇用氯化亚砜氯化可得2-氯-1-二甲氨基丙烷盐酸盐[584-49-0]。

N,N-二甲基异丙醇胺名称

[ CAS 号 ]:
108-16-7

[ 中文名 ]:
N,N-二甲基异丙醇胺

[ 英文名 ]:
Dimepranol

[中文别名 ]:

[英文别名 ]:

(±)-1-(Dimethylamino)-2-propanol
1-(Dimethylamino)-2-propanol
1-(dimethylamino)propan-2-ol
2-Propanol, 1- (dimethylamino)-
(±)-1-(N,N-Dimethylamino)-2-propanol
DL-1-(Dimethylamino)-2-propanol
2-Propanol,1-(dimethylamino)-
N,N-Dimethylisopropanolamine
EINECS 203-556-4
N,N-dimethylaminoisopropanol

N,N-二甲基异丙醇胺物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
124.0±0.0 °C at 760 mmHg

[ 熔点 ]:
-40ºC

[ 分子式 ]:
C₅H₁₃NO

[ 分子量 ]:
103.163

[ 闪点 ]:
25.6±0.0 °C

[ 精确质量 ]:
103.099716

[ PSA ]:
23.47000

[ LogP ]:
0.02

[ 外观性状 ]:
透明至淡黄色液体

[ 蒸汽密度 ]:
3.6 (vs air)

[ 蒸汽压 ]:
6.1±0.4 mmHg at 25°C

[ 折射率 ]:
1.437

[ 储存条件 ]:
库房通风低温干燥,与氧化剂分开存放

[ 稳定性 ]:
Stable. Flammable. Incompatible with strong oxidizing agents, amines, acids.

[ 水溶解性 ]:
miscible

N,N-二甲基异丙醇胺MSDS

N,N-二甲基异丙醇胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UB3150000

CHEMICAL NAME :: 2-Propanol, 1-(dimethylamino)-

CAS REGISTRY NUMBER :: 108-16-7

BEILSTEIN REFERENCE NO. :: 1209244

LAST UPDATED :: 199806

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C5-H13-N-O

MOLECULAR WEIGHT :: 103.19

WISWESSER LINE NOTATION :: QY1&1N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,563,1982

TYPE OF TEST :: Rinsed with water

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,573,1982 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1890 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 10,61,1954 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2015 No. of Facilities: 632 (estimated) No. of Industries: 20 No. of Occupations: 16 No. of Employees: 19664 (estimated) No. of Female Employees: 914 (estimated)

N,N-二甲基异丙醇胺安全信息

[ 符号 ]:

GHS02, GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H312-H314

[ 警示性声明 ]:
P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P403 + P235

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive;

[ 风险声明 (欧洲) ]:
R10;R22;R34

[ 安全声明 (欧洲) ]:
S23-S26-S36-S45

[ 危险品运输编码 ]:
UN 2734

[ WGK德国 ]:
1

[ RTECS号 ]:
UB3150000

[ 包装等级 ]:
II

[ 海关编码 ]:
29221980

N,N-二甲基异丙醇胺合成路线

N,N-二甲基异丙醇胺上下游产品

N,N-二甲基异丙醇胺上游产品

N,N-二甲基异丙醇胺下游产品

N,N-二甲基异丙醇胺制备

1.环氧丙烷法：由环氧丙烷与二甲胺反应而得。

2.氯代异丙醇法：由氯代异丙醇与二甲胺反应。

N,N-二甲基异丙醇胺海关

[ 海关编码 ]: 2922199090

[ 中文概述 ]:
2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

N,N-二甲基异丙醇胺文献

Acute toxicity and primary irritancy of alkylalkanolamines.

Vet. Hum. Toxicol. 38(6) , 422-6, (1996)

The acute handling hazards of several alkylalkanolamines were determined by investigating their potential acute toxicity and primary irritancy. Materials studied were N-methylethanolamine (MEA), N, N,...

Inosiplex: metabolism and excretion of the dimethylaminoisopropanol and p-acetamidobenzoic acid components in rhesus monkeys.

Drug Metab. Dispos. 12(2) , 199-203, (1984)

The principal excretion products derived from radiolabeled N,N-dimethylaminoisopropanol (Dip) and p-acetamidobenzoic acid (PAcBA) components of inosiplex (Isoprinosine) were identified and quantified ...

Study of methylation of nitrogen-containing compounds in the gas phase.

J. Mass Spectrom. 42(2) , 218-24, (2007)

The methyl migration between the protonated N,N-dimethylisopropylamine and other neutral aliphatic amines in the gas phase has been investigated by a hybrid external chemical ionization source ion tra...

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