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蛋白磷酸酯酶抑制剂

蛋白磷酸酯酶抑制剂用途

Calyculin A是有效,可渗透细胞的蛋白磷酸酶1 (PP1) 和蛋白磷酸酶2A (PP2A) 抑制剂,其IC50 为0.5至1 nM。

蛋白磷酸酯酶抑制剂名称

[ CAS 号 ]:
101932-71-2

[ 中文名 ]:
蛋白磷酸酯酶抑制剂

[ 英文名 ]:
Calyculin A

[英文别名 ]:

MFCD00133156
Calyculin A

蛋白磷酸酯酶抑制剂生物活性

[ 描述 ]:

Calyculin A是有效,可渗透细胞的蛋白磷酸酶1 (PP1) 和蛋白磷酸酶2A (PP2A) 抑制剂,其IC50 为0.5至1 nM。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 磷酸酶

研究领域 >> 癌症

[参考文献]

[1]. Ishihara H, et al. Calyculin A and okadaic acid: inhibitors of protein phosphatase activity. Biochem Biophys Res Commun. 1989 Mar 31;159(3):871-7.

[相关活性小分子]

蛋白磷酸酯酶抑制剂物理化学性质

[ 密度 ]:
1.25g/cm3

[ 分子式 ]:
C₅₀H₈₁N₄O₁₅P

[ 分子量 ]:
1009.17000

[ 精确质量 ]:
1008.54000

[ PSA ]:
296.80000

[ LogP ]:
5.07988

[ 折射率 ]:
1.57

[ 储存条件 ]:
2-8℃

蛋白磷酸酯酶抑制剂MSDS

详细MSDS(安全技术说明书)

蛋白磷酸酯酶抑制剂安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311 + H331-H315

[ 警示性声明 ]:
P261-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
23/24/25-38

[ 安全声明 (欧洲) ]:
36/37/39-45

[ 危险品运输编码 ]:
UN 3462 6.1/PG 3

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

蛋白磷酸酯酶抑制剂文献

A novel receptor cross-talk between the ATP receptor P2Y2 and formyl peptide receptors reactivates desensitized neutrophils to produce superoxide

Exp. Cell Res. 323(1) , 209-17, (2014)

Neutrophils express several G-protein coupled receptors (GPCRs) and they cross regulate each other. We described a novel cross-talk mechanism in neutrophils, by which signals generated by the receptor...

Detachment-induced autophagy in three-dimensional epithelial cell cultures.

Meth. Enzymol. 452 , 423-39, (2009)

Integrin-mediated cell adhesion to extracellular matrix (ECM) is critical for normal epithelial cell survival; cells deprived of ECM contact rapidly undergo apoptotic cell death, termed anoikis. Recen...

Unique features of the okadaic acid activity class of tumor promoters.

J. Cancer Res. Clin. Oncol. 125 , 150-155, (1999)

Following the first report of tumor promotion by okadaic acid in 1988, we further identified additional tumor promoters of the okadaic acid activity class, such as calyculin A and microcystin-LR. Howe...

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