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ISPA-28

ISPA-28用途

ISPA-28 是特异性的疟原虫表面阴离子通道 (PSAC) 拮抗剂。ISPA-28 直接可逆的与CLAG3 结合。

ISPA-28名称

[ CAS 号 ]:
1006335-39-2

[ 英文名 ]:
ISPA-28

[英文别名 ]:

MFCD08106635

ISPA-28生物活性

[ 描述 ]:

ISPA-28 是特异性的疟原虫表面阴离子通道 (PSAC) 拮抗剂。ISPA-28 直接可逆的与CLAG3 结合。

[ 相关类别 ]:

研究领域 >> 感染

[体外研究]

ISPA-28仅作为Dd2通道的抑制剂有效(Dd2和HB3通道的K0.5值分别为56 nM和43μM)[2]。

[参考文献]

[1]. Sanjay A Desai, et al. Ion and Nutrient Uptake by Malaria Parasite-Infected Erythrocytes.

[2]. Wang Nguitragool, et al. Proteolysis at a Specific Extracellular Residue Implicates Integral Membrane CLAG3 in Malaria Parasite Nutrient Channels.

ISPA-28物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 分子式 ]:
C₂₁H₂₄N₆O₃

[ 分子量 ]:
408.454

[ 精确质量 ]:
408.190979

[ LogP ]:
0.18

[ 折射率 ]:
1.672

ISPA-28安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

ISPA-28文献

An epigenetic antimalarial resistance mechanism involving parasite genes linked to nutrient uptake.

J. Biol. Chem. 288(27) , 19429-40, (2013)

Acquired antimalarial drug resistance produces treatment failures and has led to periods of global disease resurgence. In Plasmodium falciparum, resistance is known to arise through genome-level chang...

Malaria parasite mutants with altered erythrocyte permeability: a new drug resistance mechanism and important molecular tool.

Future Microbiol. 5(1) , 81-97, (2010)

Erythrocytes infected with plasmodia, including those that cause human malaria, have increased permeability to a diverse collection of organic and inorganic solutes. While these increases have been kn...

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