ISPA-28

更新时间：2025-08-25 17:08:17

ISPA-28结构式	常用名	ISPA-28	英文名	ISPA-28
	CAS号	1006335-39-2	分子量	408.454
	密度	1.4±0.1 g/cm3	沸点	N/A
	分子式	C₂₁H₂₄N₆O₃	熔点	N/A
	MSDS	美版	闪点	N/A

ISPA-28用途

ISPA-28 是特异性的疟原虫表面阴离子通道 (PSAC) 拮抗剂。ISPA-28 直接可逆的与CLAG3 结合。

英文名	N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-4,5-dihydro-1,2-oxazole-5-carboxamide
英文别名	更多

描述	ISPA-28 是特异性的疟原虫表面阴离子通道 (PSAC) 拮抗剂。ISPA-28 直接可逆的与CLAG3 结合。
相关类别	研究领域 >> 感染
体外研究	ISPA-28仅作为Dd2通道的抑制剂有效(Dd2和HB3通道的K0.5值分别为56 nM和43μM)[2]。
参考文献	[1]. Sanjay A Desai, et al. Ion and Nutrient Uptake by Malaria Parasite-Infected Erythrocytes. [2]. Wang Nguitragool, et al. Proteolysis at a Specific Extracellular Residue Implicates Integral Membrane CLAG3 in Malaria Parasite Nutrient Channels.

密度	1.4±0.1 g/cm3
分子式	C₂₁H₂₄N₆O₃
分子量	408.454
精确质量	408.190979
LogP	0.18
折射率	1.672

危险品运输编码	NONH for all modes of transport

An epigenetic antimalarial resistance mechanism involving parasite genes linked to nutrient uptake.

J. Biol. Chem. 288(27) , 19429-40, (2013)

Acquired antimalarial drug resistance produces treatment failures and has led to periods of global disease resurgence. In Plasmodium falciparum, resistance is known to arise through genome-level chang...

Malaria parasite mutants with altered erythrocyte permeability: a new drug resistance mechanism and important molecular tool.

Future Microbiol. 5(1) , 81-97, (2010)

Erythrocytes infected with plasmodia, including those that cause human malaria, have increased permeability to a diverse collection of organic and inorganic solutes. While these increases have been kn...

5-Isoxazolecarboxamide, N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-4,5-dihydro-

N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-4,5-dihydro-1,2-oxazole-5-carboxamide

MFCD08106635