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喷他脒

喷他脒用途

Pentamidine(MP-601205)是抗生素。

喷他脒作用

本品作用机制尚不够清楚，可能干扰核苷酸生物合成和DNA的复制，也可干扰叶酸盐的转换。

喷他脒名称

[ CAS 号 ]:
100-33-4

[ 中文名 ]:
喷他脒

[ 英文名 ]:
Pentamidine

[中文别名 ]:

4,4'-二脒基二苯氧基戊烷

[英文别名 ]:

4,4'-(Pentane-1,5-diylbis(oxy))dibenzimidamide
pentamidine
EINECS 202-841-0

喷他脒生物活性

[ 描述 ]:

Pentamidine(MP-601205)是抗生素。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物

研究领域 >> 感染

[参考文献]

[1]. Nguewa, P.A., et al., Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers, 2005. 2(10): p. 1387-400.

[2]. Pathak, M.K., et al., Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Mol Cancer Ther, 2002. 1(14): p. 1255-64.

[相关活性小分子]

喷他脒物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
539.4±60.0 °C at 760 mmHg

[ 熔点 ]:
186ºC (dec.)

[ 分子式 ]:
C₁₉H₂₄N₄O₂

[ 分子量 ]:
340.419

[ 闪点 ]:
280.0±32.9 °C

[ 精确质量 ]:
340.189911

[ PSA ]:
118.20000

[ LogP ]:
2.47

[ 外观性状 ]:
橙色固体

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.593

[ 储存条件 ]:
-20°C Freezer, Under Inert Atmosphere

喷他脒毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV6475000

CHEMICAL NAME :: Benzamidine, 4,4'-(pentamethylenedioxy)di-

CAS REGISTRY NUMBER :: 100-33-4

BEILSTEIN REFERENCE NO. :: 3159790

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C19-H24-N4-O2

MOLECULAR WEIGHT :: 340.47

WISWESSER LINE NOTATION :: MUYZR DO5OR DYZUM

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 28 mg/kg/1W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - body temperature increase

REFERENCE :: AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 145,2247,1985

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 4 mg/kg/3D

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature increase

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 246,338,1944

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 4 mg/kg

TOXIC EFFECTS :: Endocrine - hypoglycemia

REFERENCE :: AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 99,128,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,794,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BSCFAS Bulletin de la Societe Chimique de France. (CDR-Centrale des Revues, 11, rue Gossin, F-92543 Montrouge Cedex, France) V.1- 1864- Volume(issue)/page/year: -,376,1968

喷他脒安全信息

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
UN 3249

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2925290090

喷他脒合成路线

详细合成路线

喷他脒上下游产品

喷他脒上游产品

喷他脒下游产品

喷他脒海关

[ 海关编码 ]: 2925290090

[ 中文概述 ]:
2925290090 其他亚胺及其衍生物，以及它们的盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

喷他脒