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N,N,N',N'-四甲基对苯二胺

N,N,N',N'-四甲基对苯二胺用途

N,N,N′,N′-Tetramethyl-p-phenylenediamine (TMPD) 是一种氧化还原指示剂。N,N,N′,N′-Tetramethyl-p-phenylenediamine可用于细胞呼吸损伤的研究。

N,N,N',N'-四甲基对苯二胺名称

[ CAS 号 ]:
100-22-1

[ 中文名 ]:
N,N,N',N'-四甲基对苯二胺

[ 英文名 ]:
Wurster's blue

[中文别名 ]:

N,N,N’,N’-四甲基对苯二胺

[英文别名 ]:

1,4-Benzenediamine, N,N,N,N-tetramethyl-
tetramethylphenylenediamine
Wurster's blue
N,N,N′,N′-tetramethyl-p-phenylenediamine
EINECS 202-831-6
N,N,N‘,N‘-Tetramethyl-p-phenylenediamine
N,N,N',N'-Tetramethyl-1,4-benzenediamine
N,N,N′,N′-tetramethyl-para-phenylenediamine
1-N,1-N,4-N,4-N-tetramethylbenzene-1,4-diamine
N,N,N′,N′-Tetramethyl-1,4-phenylenediamine

N,N,N',N'-四甲基对苯二胺生物活性

[ 描述 ]:

N,N,N′,N′-Tetramethyl-p-phenylenediamine (TMPD) 是一种氧化还原指示剂。N,N,N′,N′-Tetramethyl-p-phenylenediamine可用于细胞呼吸损伤的研究。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[参考文献]

[1]. Zhou S, Yao Y, et al. A cytochrome c-enhanced peroxidation reaction with potential use in screening dietary antioxidants. J Pharm Biomed Anal. 2004 Mar 10;34(5):1057-61.

[2]. Sarti P, et al. Permeability of rat heart myocytes to cytochrome c. Cell Mol Life Sci. 1999 Dec;56(11-12):1061-9.

N,N,N',N'-四甲基对苯二胺物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
260.6±13.0 °C at 760 mmHg

[ 熔点 ]:
49-51 °C(lit.)

[ 分子式 ]:
C₁₀H₁₆N₂

[ 分子量 ]:
164.25

[ 闪点 ]:
104.9±7.7 °C

[ 精确质量 ]:
164.131348

[ PSA ]:
6.48000

[ LogP ]:
2.08

[ 外观性状 ]:
紫色至棕色结晶粉末

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.578

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

[ 稳定性 ]:
Stable, but may be air or light sensitive. Combustible. Incompatible with acids, acid chlorides, acid anhydrides, oxidizing agents.

[ 水溶解性 ]:
slightly in cold, more in hot water

N,N,N',N'-四甲基对苯二胺MSDS

N,N,N',N'-四甲基对苯二胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ST4200000

CHEMICAL NAME :: p-Phenylenediamine, N,N,N',N'-tetramethyl-

CAS REGISTRY NUMBER :: 100-22-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C10-H16-N2

MOLECULAR WEIGHT :: 164.28

WISWESSER LINE NOTATION :: 1N1&R DN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 780 mg/m3/10M

TOXIC EFFECTS :: Behavioral - irritability Lungs, Thorax, or Respiration - acute pulmonary edema

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 42 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 23700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 241,175,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3675 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 232 (estimated) No. of Female Employees: 130 (estimated)

N,N,N',N'-四甲基对苯二胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H332

[ 警示性声明 ]:
P280

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S28-S28A

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
1

[ RTECS号 ]:
ST4200000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

[ 海关编码 ]:
2921519090

N,N,N',N'-四甲基对苯二胺合成路线

N,N,N',N'-四甲基对苯二胺上下游产品

N,N,N',N'-四甲基对苯二胺上游产品

N,N,N',N'-四甲基对苯二胺下游产品

N,N,N',N'-四甲基对苯二胺制备

1.由草酸二乙酯和丙酮反应得到

2.以对苯二胺为原料，与氯乙酸反应生成苯基二亚氨基四乙酸，然后进行脱羧反应，制得成品。反应式如下：

N,N,N',N'-四甲基对苯二胺海关

[ 海关编码 ]: 2921519090

[ 中文概述 ]:
2921519090. 间-、对-苯二胺、二氨基甲苯等〔包括衍生物及它们的盐〕. 增值税率:17.0%. 退税率:17.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921519090. o-, m-, p-phenylenediamine, diaminotoluenes, and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:17.0%. . MFN tariff:6.5%. General tariff:30.0%

N,N,N',N'-四甲基对苯二胺文献

Cation binding site of cytochrome c oxidase: progress report.

Biochim. Biophys. Acta 1837(7) , 1188-95, (2014)

Cytochrome c oxidase from bovine heart binds Ca(2+) reversibly at a specific Cation Binding Site located near the outer face of the mitochondrial membrane. Ca(2+) shifts the absorption spectrum of hem...

Re-evaluation of the near infrared spectra of mitochondrial cytochrome c oxidase: Implications for non invasive in vivo monitoring of tissues.

Biochim. Biophys. Acta 1837(11) , 1882-91, (2014)

We re-determined the near infrared (NIR) spectral signatures (650-980nm) of the different cytochrome c oxidase redox centres, in the process separating them into their component species. We confirm th...

Synthesis, characterization, evaluation and molecular dynamics studies of 5, 6-diphenyl-1,2,4-triazin-3(2H)-one derivatives bearing 5-substituted 1,3,4-oxadiazole as potential anti-inflammatory and analgesic agents.

Eur. J. Med. Chem. 101 , 81-95, (2015)

A series of triazin-3(2H)-one derivatives bearing 1,3,4-oxadiazole (4a-4o) were synthesized, characterized and evaluated for anti-inflammatory and analgesic activities. Preliminary in vitro anti-infla...

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